Evidence map›Paper›PMID 30840905›Full record

ArticleNeuroImage2019

Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites.

Mark Mikkelsen, Daniel L Rimbault, Peter B Barker, Pallab K Bhattacharyya, Maiken K Brix, Pieter F Buur, Kim M Cecil, Kimberly L Chan, David Y-T Chen, Alexander R Craven and 56 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 5 syntheses or guidelines pooled it, 110 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Trial
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  11. Observational
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  19. Statistical non-independence of brain metabolite concentrations whether normalized to creatine or water.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors at 20 institutions in 10 countries.

Mark MikkelsenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: mmikkel5@jhmi.edu.
Daniel L RimbaultDivision of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.
Peter B BarkerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Pallab K BhattacharyyaImaging Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Maiken K BrixDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.
Pieter F BuurSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands.
Kim M CecilDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kimberly L ChanRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David Y-T ChenDepartment of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
Alexander R CravenDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway.
Koen CuypersMovement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium; REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium.
Michael DackoDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Niall W DuncanBrain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan.
Ulrike DydakSchool of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
David A EdmondsonSchool of Health Sciences, Purdue University, West Lafayette, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Gabriele EndeDepartment of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany.
Lars ErslandDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
Megan A ForbesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Fei GaoShandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Ian GreenhouseDepartment of Human Physiology, University of Oregon, Eugene, OR, USA.
Ashley D HarrisDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Naying HeDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stefanie HebaDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Nigel HoggardAcademic Unit of Radiology, University of Sheffield, Sheffield, UK.
Tun-Wei HsuDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Jacobus F A JansenDepartment of Radiology, Maastricht University Medical Center, Maastricht, the Netherlands.
Alayar KangarluDepartment of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Thomas LangeDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
R Marc LebelGE Healthcare, Calgary, AB, Canada.
Yan LiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chien-Yuan E LinGE Healthcare, Taipei, Taiwan.
Jy-Kang LiouDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Jiing-Feng LirngDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Feng LiuNew York State Psychiatric Institute, New York, NY, USA.
Joanna R LongDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, USA; National High Magnetic Field Laboratory, Gainesville, FL, USA.
Ruoyun MaSchool of Health Sciences, Purdue University, West Lafayette, IN, USA; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Celine MaesMovement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium.
Marta Moreno-OrtegaDepartment of Psychiatry, Columbia University, New York, NY, USA.
Scott O MurrayDepartment of Psychology, University of Washington, Seattle, WA, USA.
Sean NoahCenter for Mind and Brain, University of California, Davis, Davis, CA, USA.
Ralph NoeskeGE Healthcare, Berlin, Germany.
Michael D NoseworthyDepartment of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Eric C PorgesDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
James J PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Nicolaas A J PutsRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Timothy P L RobertsDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Markus SackDepartment of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany.
Napapon SailasutaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Muhammad G SalehRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Michael-Paul SchallmoDepartment of Psychology, University of Washington, Seattle, WA, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Nicholas SimardSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Diederick StoffersSpinoza Centre for Neuroimaging, Amsterdam, the Netherlands.
Stephan P SwinnenMovement Control & Neuroplasticity Research Group, Department of Movement Sciences, Group of Biomedical Sciences, KU Leuven, Leuven, Belgium; Leuven Brain Institute (LBI), KU Leuven, Leuven, Belgium.
Martin TegenthoffDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Peter TruongResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Guangbin WangShandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Iain D WilkinsonAcademic Unit of Radiology, University of Sheffield, Sheffield, UK.
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Adam J WoodsDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Hongmin XuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chencheng ZhangDepartment of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Helge J ZöllnerDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Johns Hopkins University · USCentre for Addiction and Mental Health · CASiemens Healthcare (Germany) · DEBG University Hospital Bergmannsheil Bochum · DEColumbia University · USNational Yang Ming Chiao Tung University · TWShanghai Jiao Tong University · CNHaukeland University Hospital · NOSpinoza Centre for Neuroimaging · NLTaipei Veterans General Hospital · TWUniversity of Bergen · NOUniversity of Florida Health · USUniversity of Toronto · CACentral Institute of Mental Health · DECentre for Movement Disorders · CACincinnati Children's Hospital Medical Center · USCleveland Clinic Lerner College of Medicine · USGeneral Electric (Canada) · CAHasselt University · BEIndiana University School of Medicine

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Augmenting Cognitive Training in Older Adults - The ACT GrantR01AG054077 · NIA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, MARSISKE, MICHAEL · 2016 to 2020
$6.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Vision Science Training Program: Cornea to CortexT32EY015387 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI MARIE E BURNS · 2003 to 2026
$4.8M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
2/2-Anomalous Motor Physiology in ADHDR01MH095014 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI GILBERT, DONALD L · 2012 to 2024
$3.3M
GABAergic Sensorimotor Dysfunction in Tourette SyndromeR01NS096207 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI GILBERT, DONALD L, MOSTOFSKY, STEWART H · 2016 to 2020
$2.9M
Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7M
Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
3T MRI Scanner dedicated to Life Sciences ResearchS10OD012336 · OD · PURDUE UNIVERSITY · PI DYDAK, ULRIKE · 2015 to 2015
$2.0M
Neuroimaging mechanisms of overlap between alcoholism and bipolar disorderK23AA020842 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2012 to 2016
$835k
NEI NIH HHS F32 EY025121NEI NIH HHS T32 EY015387NIAAA NIH HHS K01 AA025306NIAAA NIH HHS K23 AA020842NIAAA NIH HHS R01 AA025365NIA NIH HHS K01 AG050707NIA NIH HHS R01 AG054077NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NICHD NIH HHS U54 HD083091NIEHS NIH HHS F31 ES028081NIH HHS S10 OD012336NIMH NIH HHS R00 MH107719NIMH NIH HHS R01 MH095014NINDS NIH HHS R01 NS096207Wellcome Trust
6 · The paper itself

Abstract

Accurate and reliable quantification of brain metabolites measured in vivo using

Indexed as

AdolescentAdultBrainDatasets as TopicFemalegamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyMaleReference ValuesWaterYoung Adultgamma-Aminobutyric AcidWaterEditingGABAMEGA-PRESSMRSQuantificationTissue correction

Identifiers

PMID30840905
PMCPMC6818968
OpenAlexW2918802475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.