Evidence map›Paper›PMID 30840900›Full record

ArticleCell reports2019

Functional Access to Neuron Subclasses in Rodent and Primate Forebrain.

Preeti Mehta, Lauren Kreeger, Dennis C Wylie, Jagruti J Pattadkal, Tara Lusignan, Matthew J Davis, Gergely F Turi, Wen-Ke Li, Matthew P Whitmire, Yuzhi Chen and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 81 citations in OpenAlex.

  1. Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Neuropixels reveal structure-function relationships in monkey V1bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Molecular therapy. Methods & clinical development · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Preeti MehtaCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Lauren KreegerCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Dennis C WylieCenter for Computational Biology and Bioinformatics, University of Texas, Austin, TX 78712, USA.
Jagruti J PattadkalCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Tara LusignanCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Matthew J DavisCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Gergely F TuriKavli Institute for Brain Science, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA.
Wen-Ke LiKavli Institute for Brain Science, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA.
Matthew P WhitmireCenter for Perceptual Systems, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA; Department of Psychology, University of Texas, Austin, TX 78712, USA.
Yuzhi ChenCenter for Perceptual Systems, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA; Department of Psychology, University of Texas, Austin, TX 78712, USA.
Bridget L KajsCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Eyal SeidemannCenter for Perceptual Systems, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA; Department of Psychology, University of Texas, Austin, TX 78712, USA.
Nicholas J PriebeCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA.
Attila LosonczyKavli Institute for Brain Science, Columbia University, New York, NY 10027, USA; Department of Neuroscience, Columbia University, New York, NY 10027, USA.
Boris V ZemelmanCenter for Learning and Memory, University of Texas, Austin, TX 78712, USA; Department of Neuroscience, University of Texas, Austin, TX 78712, USA. Electronic address: zemelmanb@mail.clm.utexas.edu.
The University of Texas at Austin · USColumbia University · US

Funding

Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI BUZSAKI, GYORGY, LISMAN, JOHN E · 2017 to 2021
$13.2M
Linking Neural Population Activity and Visual PerceptionR01EY016454 · NEI · UNIVERSITY OF TEXAS AUSTIN · PI SEIDEMANN, EYAL J · 2005 to 2024
$6.6M
Neural ensembles underlying natural tracking behaviorU01NS094330 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI FIETE, ILA R., HUK, ALEXANDER C · 2015 to 2018
$3.2M
An optical-genetic toolbox for reading and writing neural population codes in functional mapsU01NS099720 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI GEISLER, WILSON S, SEIDEMANN, EYAL J · 2016 to 2018
$1.8M
2-photon microscope for in vivo functional imaging of neuronal circuitsS10OD018464 · OD · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MOORE, HOLLY MARIE · 2015 to 2015
$847k
NEI NIH HHS R01 EY016454NIH HHS S10 OD018464NINDS NIH HHS U01 NS094330NINDS NIH HHS U01 NS099720NINDS NIH HHS U19 NS104590
6 · The paper itself

Abstract

Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the rodent and primate. Using a set intersection approach, which relies on two co-active promoters, we can restrict heterologous protein expression to cortical and hippocampal somatostatin-positive and parvalbumin-positive interneurons. With an orthogonal set difference method, we can enrich for subclasses of neuropeptide-Y-positive GABAergic interneurons by effectively subtracting the expression pattern of one promoter from that of another. These methods harness the complexity of gene expression patterns in the brain and significantly expand the number of genetically tractable neuron classes across mammals.

Indexed as

AnimalsBrainCallithrixMiceMice, TransgenicNeuronsPrimatesRodentiaadeno-associated viruscell type-specific promoterfunctional in vivo imaginginhibitory neuronsmacaquemarmosetneuropeptide-Yparvalbuminrodentsomatostatin

Identifiers

PMID30840900
PMCPMC6509701
OpenAlexW2919724853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.