Evidence map›Paper›PMID 30840802›Full record

ArticleThe Korean journal of parasitology2019

Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep.

Liu Tianli, Wang Xifeng, Tian Zhenzhong, Wang Lixia, Zhang Xingxing, Qiao Jun, Meng Qingling, Gong Shasha, Chen Ying, Cai Xuepeng

Open access · diamondAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Liu TianliCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Wang XifengCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Tian ZhenzhongCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Wang LixiaCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Zhang XingxingState Key Laboratory for Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi, Xinjiang 832000, China.
Qiao JunCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Meng QinglingCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Gong ShashaCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Chen YingCollege of Animal Science & Technology, Shihezi University, Shihezi, Xinjiang 832003, China.
Cai XuepengState Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China.
Shihezi University · CNChinese Academy of Agricultural Sciences · CNXinjiang Academy of Agricultural and Reclamation Science · CN

Funding

National Key Research and Development Program 2017YFD0501200Xinjiang Autonomous Region graduate innovation project XJGRI2014059Xinjiang Production and Construction Corps 2016AH006
6 · The paper itself

Abstract

Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep.

Indexed as

AnimalsAntibodies, HelminthAntigens, HelminthEchinococcosisEchinococcusEnzyme-Linked Immunosorbent AssayEpitopesEscherichia coliIncidenceRecombinant Fusion ProteinsSensitivity and SpecificitySerologic TestsSheepSheep DiseasesAntibodies, HelminthAntigens, HelminthEpitopesRecombinant Fusion Proteinsantigencystic echinococcosisfusion proteinindirect ELISAmulti-epitopeserodiagnosticsheep

Identifiers

PMID30840802
PMCPMC6409221
OpenAlexW2917742253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.