Evidence map›Paper›PMID 30840739›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2018

PROSTATEx Challenges for computerized classification of prostate lesions from multiparametric magnetic resonance images.

Samuel G Armato, Henkjan Huisman, Karen Drukker, Lubomir Hadjiiski, Justin S Kirby, Nicholas Petrick, George Redmond, Maryellen L Giger, Kenny Cha, Artem Mamonov and 2 more

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samuel G ArmatoThe University of Chicago, Department of Radiology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0002-5428-7997
Henkjan HuismanRadboud University Medical Center, Department of Radiology and Nuclear Medicine, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0001-6753-3221
Karen DrukkerThe University of Chicago, Department of Radiology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0001-6544-3476
Lubomir HadjiiskiUniversity of Michigan, Department of Radiology, Ann Arbor, Michigan, United States.
Justin S KirbyFrederick National Laboratory for Cancer Research, Cancer Imaging Program, Frederick, Maryland, United States.
Nicholas PetrickU.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland, United States.ORCID https://orcid.org/0000-0001-5167-8899
George RedmondNational Cancer Institute, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, Bethesda, Maryland, United States.ORCID https://orcid.org/0000-0003-3367-1786
Maryellen L GigerThe University of Chicago, Department of Radiology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0001-5482-9728
Kenny ChaUniversity of Michigan, Department of Radiology, Ann Arbor, Michigan, United States.ORCID https://orcid.org/0000-0003-3847-7448
Artem MamonovMGH/Harvard Medical School, Boston, Massachusetts, United States.
Jayashree Kalpathy-CramerMGH/Harvard Medical School, Boston, Massachusetts, United States.ORCID https://orcid.org/0000-0001-8906-9618
Keyvan FarahaniNational Cancer Institute, Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, Bethesda, Maryland, United States.

Funding

Quantitative Image Informatics for Cancer Research (QIICR)U24CA180918 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEDOROV, ANDRIY, KIKINIS, RON · 2013 to 2017
$4.0M
Informatics Tools for Optimized Imaging Biomarkers for Cancer Research&DiscoveryU24CA180927 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, ROSEN, BRUCE R · 2014 to 2018
$3.4M
Quantitative MRI of Glioblastoma ResponseU01CA154601 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE · 2011 to 2016
$3.4M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS U01 CA154601NCI NIH HHS U24 CA180918NCI NIH HHS U24 CA180927
6 · The paper itself

Abstract

Grand challenges stimulate advances within the medical imaging research community; within a competitive yet friendly environment, they allow for a direct comparison of algorithms through a well-defined, centralized infrastructure. The tasks of the two-part PROSTATEx Challenges (the PROSTATEx Challenge and the PROSTATEx-2 Challenge) are (1) the computerized classification of clinically significant prostate lesions and (2) the computerized determination of Gleason Grade Group in prostate cancer, both based on multiparametric magnetic resonance images. The challenges incorporate well-vetted cases for training and testing, a centralized performance assessment process to evaluate results, and an established infrastructure for case dissemination, communication, and result submission. In the PROSTATEx Challenge, 32 groups apply their computerized methods (71 methods total) to 208 prostate lesions in the test set. The area under the receiver operating characteristic curve for these methods in the task of differentiating between lesions that are and are not clinically significant ranged from 0.45 to 0.87; statistically significant differences in performance among the top-performing methods, however, are not observed. In the PROSTATEx-2 Challenge, 21 groups apply their computerized methods (43 methods total) to 70 prostate lesions in the test set. When compared with the reference standard, the quadratic-weighted kappa values for these methods in the task of assigning a five-point Gleason Grade Group to each lesion range from

Indexed as

Gleason Grade Groupgrand challengeimaging biomarkerlesion classificationmultiparametric magnetic resonance imagesprostate cancer

Identifiers

PMID30840739
PMCPMC6228312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.