Evidence map›Paper›PMID 30840719›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2018

Classification of suspicious lesions on prostate multiparametric MRI using machine learning.

Deukwoo Kwon, Isildinha M Reis, Adrian L Breto, Yohann Tschudi, Nicole Gautney, Olmo Zavala-Romero, Christopher Lopez, John C Ford, Sanoj Punnen, Alan Pollack and 1 more

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. MRI-based patient selection for active surveillance in prostate cancer using U-Found: a generalized deep learning model.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
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  16. Prostate Cancer Radiogenomics-From Imaging to Molecular Characterization.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deukwoo KwonUniversity of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biostatistics and Bioinformatics Shared Resource, Miami, Florida, United States.ORCID https://orcid.org/0000-0001-5376-5320
Isildinha M ReisUniversity of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Biostatistics and Bioinformatics Shared Resource, Miami, Florida, United States.
Adrian L BretoUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.ORCID https://orcid.org/0000-0002-4958-2991
Yohann TschudiUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.
Nicole GautneyUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.
Olmo Zavala-RomeroUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.
Christopher LopezUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.
John C FordUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.ORCID https://orcid.org/0000-0003-4025-5836
Sanoj PunnenUniversity of Miami Miller School of Medicine, Department of Urology, Miami, Florida, United States.
Alan PollackUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.
Radka StoyanovaUniversity of Miami Miller School of Medicine, Department of Radiation Oncology, Miami, Florida, United States.

Funding

MRI Imaging and Genetic Signatures to Manage Prostate Cancer OverdiagnosisR01CA189295 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI POLLACK, ALAN · 2014 to 2018
$3.2M
(PQC4) Habitats in Prostate CancerR01CA190105 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI BALAGURUNATHAN, YOGANAND, GILLIES, ROBERT J. · 2014 to 2017
$2.8M
NCI NIH HHS R01 CA189295NCI NIH HHS R01 CA190105
6 · The paper itself

Abstract

We present a radiomics-based approach developed for the SPIE-AAPM-NCI PROSTATEx challenge. The task was to classify clinically significant prostate cancer in multiparametric (mp) MRI. Data consisted of a "training dataset" (330 suspected lesions from 204 patients) and a "test dataset" (208 lesions/140 patients). All studies included T2-weighted (T2-W), proton density-weighted, dynamic contrast enhanced, and diffusion-weighted imaging. Analysis of the images was performed using the MIM imaging platform (MIM Software, Cleveland, Ohio). Prostate and peripheral zone contours were manually outlined on the T2-W images. A workflow for rigid fusion of the aforementioned images to T2-W was created in MIM. The suspicious lesion was outlined using the high b-value image. Intensity and texture features were extracted on four imaging modalities and characterized using nine histogram descriptors: 10%, 25%, 50%, 75%, 90%, mean, standard deviation, kurtosis, and skewness (216 features). Three classification methods were used: classification and regression trees (CART), random forests, and adaptive least absolute shrinkage and selection operator (LASSO). In the held out by the organizers test dataset, the areas under the curve (AUCs) were: 0.82 (random forests), 0.76 (CART), and 0.76 (adaptive LASSO). AUC of 0.82 was the fourth-highest score of 71 entries (32 teams) and the highest for feature-based methods.

Indexed as

machine learningmultiparametric MRIprostate cancer

Identifiers

PMID30840719
PMCPMC6126494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.