ArticlePloS one2019
AutonoMouse: High throughput operant conditioning reveals progressive impairment with graded olfactory bulb lesions.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
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- Stable clique membership in male mouse societies requires oxytocin-enabled social sensory states.Nature communications · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
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- High-speed odor sensing using miniaturized electronic nose.Science advances · 2024Article
- The Switchmaze: an open-design device for measuring motivation and drive switching in mice.Peer community journal · 2024Article
- Adaptive olfactory circuitry restores function despite severe olfactory bulb degeneration.Current biology : CB · 2023Article
- IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system.Frontiers in behavioral neuroscience · 2023Review
- Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions.International journal of molecular sciences · 2022Review
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Getting out the caliper: Behavioral quantification of perceptual odor similarity.Cell reports methods · 2022Article
- Article
- Article
- Learning Set Formation and Reversal Learning in Mice During High-Throughput Home-Cage-Based Olfactory Discrimination.Frontiers in behavioral neuroscience · 2021Article
- An automated homecage system for multiwhisker detection and discrimination learning in mice.PloS one · 2020Article
- Odor Stimuli: Not Just Chemical Identity.Frontiers in physiology · 2019Review
- Neural Correlates of Learning Pure Tones or Natural Sounds in the Auditory Cortex.Frontiers in neural circuits · 2019Article
- High-Throughput Automated Olfactory Phenotyping of Group-Housed Mice.Frontiers in behavioral neuroscience · 2019Article
- Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Operant conditioning is a crucial tool in neuroscience research for probing brain function. While molecular, anatomical and even physiological techniques have seen radical increases in throughput, efficiency, and reproducibility in recent years, behavioural tools have somewhat lagged behind. Here we present a fully automated, high-throughput system for self-initiated conditioning of up to 25 group-housed, radio-frequency identification (RFID) tagged mice over periods of several months and >106 trials. We validate this "AutonoMouse" system in a series of olfactory behavioural tasks and show that acquired data is comparable to previous semi-manual approaches. Furthermore, we use AutonoMouse to systematically probe the impact of graded olfactory bulb lesions on olfactory behaviour, demonstrating that while odour discrimination in general is robust to even most extensive disruptions, small olfactory bulb lesions already impair odour detection. Discrimination learning of similar mixtures as well as learning speed are in turn reliably impacted by medium lesion sizes. The modular nature and open-source design of AutonoMouse should allow for similar robust and systematic assessments across neuroscience research areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.