ArticlePloS one2019
Early predictors of outcomes of hospitalization for cirrhosis and assessment of the impact of race and ethnicity at safety-net hospitals.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review.Canadian journal of gastroenterology & hepatology · 2024Pooled it
- A randomized study of ceftriaxone for the prevention of infections in hospitalized patients with advanced cirrhosis.Hepatology communications · 2024Trial
- MELD and the Risk of Mortality Between Black and White Patients with Advanced Fibrosis.Digestive diseases and sciences · 2026Article
- Predictors of 30-Day Readmission in Patients With Cirrhosis: A Retrospective Cohort Study.Cureus · 2026Article
- Readmission rates among patients with cirrhosis across different follow-up periods and prevalence of major complications: a systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2026Article
- Albumin prevents kidney injury but is underutilized in a cohort of patients undergoing large-volume paracentesis.Hepatology communications · 2025Article
- Health disparities in cirrhosis care and liver transplantation.Nature reviews. Gastroenterology & hepatology · 2025Review
- Inpatient Versus Outpatient MRI? Outcomes for Hospitalized Patients With New Liver Masses.Journal of community hospital internal medicine perspectives · 2025Article
- Article
- Discharge Outcomes of Hospitalized Patients with New Onset Decompensated Cirrhosis.Digestive diseases and sciences · 2024Article
- Care for Vulnerable Populations with Chronic Liver Disease: A Safety-Net Perspective.Healthcare (Basel, Switzerland) · 2023Review
- Factors Associated With Liver Transplant Referral Among Patients With Cirrhosis at Multiple Safety-Net Hospitals.JAMA network open · 2023Article
- Patient-Reported Outcome Measures Modestly Enhance Prediction of Readmission in Patients with Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Compound Sarcopenia in Hospitalized Patients with Cirrhosis Worsens Outcomes with Increasing Age.Nutrients · 2021Article
- Racial disparities of Black Americans hospitalized for decompensated liver cirrhosis.BMC gastroenterology · 2020Article
- Development and Validation of a Model to Predict Acute Kidney Injury in Hospitalized Patients With Cirrhosis.Clinical and translational gastroenterology · 2019Article
- Recurrent and Treatment-Unresponsive Spontaneous Bacterial Peritonitis Worsens survival in Decompensated Liver Cirrhosis.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundSafety-net hospitals provide care for racially/ethnically diverse and disadvantaged urban populations. Their hospitalized patients with cirrhosis are relatively understudied and may be vulnerable to poor outcomes and racial/ethnic disparities.
aimsTo examine the outcomes of patients with cirrhosis hospitalized at regionally diverse safety-net hospitals and the impact of race/ethnicity.
methodsA study of patients with cirrhosis hospitalized at 4 safety-net hospitals in 2012 was conducted. Demographic, clinical factors, and outcomes were compared between centers and racial/ethnic groups. Study endpoints included mortality and 30-day readmission.
resultsIn 2012, 733 of 1,212 patients with cirrhosis were hospitalized for liver-related indications (median age 55 years, 65% male). The cohort was racially diverse (43% White, 25% black, 22% Hispanic, 3% Asian) with cirrhosis related to alcohol and viral hepatitis in 635 (87%) patients. Patients were hospitalized mainly for ascites (35%), hepatic encephalopathy (20%) and gastrointestinal bleeding (GIB) (17%). Fifty-four (7%) patients died during hospitalization and 145 (21%) survivors were readmitted within 30 days. Mortality rates ranged from 4 to 15% by center (p = .007) and from 3 to 10% by race/ethnicity (p = .03), but 30-day readmission rates were similar. Mortality was associated with Model for End-stage Liver Disease (MELD), acute-on-chronic liver failure, hepatocellular carcinoma, sodium and white blood cell count. Thirty-day readmission was associated with MELD and Charlson Comorbidity Index >4, with lower risk for GIB. We did not observe geographic or racial/ethnic differences in hospital outcomes in the risk-adjusted analysis.
conclusionsHospital mortality and 30-day readmission in patients with cirrhosis at safety-net hospitals are associated with disease severity and comorbidities, with lower readmissions in patients admitted for GIB. Despite geographic and racial/ethnic differences in hospital mortality, these factors were not independently associated with mortality.
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