ArticleCornea2019
Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients With Keratoconus.
Article in Cornea, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Femtosecond laser-assisted stromal keratophakia for keratoconus: A systemic review and meta-analysis.International ophthalmology · 2021Pooled it
- Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus.International ophthalmology · 2021Pooled it
- The Preservation and Reuse of Lenticules Extracted via Small Incision Lenticule Extraction (SMILE): A Narrative Review.Bioengineering (Basel, Switzerland) · 2025Review
- Long-term results of allogenic corneal lenticule of hyperopic SMILE for post-LASIK ectasia.iScience · 2024Article
- Banking of post-SMILE stromal lenticules for additive keratoplasty: A new challenge for eye banks?International ophthalmology · 2024Review
- In vivo confocal microscopy evaluation of infiltrated immune cells in corneal stroma treated with cell therapy in advanced keratoconus.Journal of ophthalmic inflammation and infection · 2024Article
- Treatment of superficial corneal opacities with corneal stromal lenticule obtained through SMILE surgery.International journal of ophthalmology · 2024Article
- Applications of SMILE-extracted lenticules in ophthalmology.International journal of ophthalmology · 2024Review
- New dawn for keratoconus treatment: potential strategies for corneal stromal regeneration.Stem cell research & therapy · 2023Review
- The new future perspective in corneal tissue utilisation - methods of preparation and preservation.BMC ophthalmology · 2023Article
- Epikeratophakia for Keratoconus: A Case Report with 30 Years of Follow-Up.Case reports in ophthalmological medicine · 2023Article
- Preservation of corneal stromal lenticule: review.Cell and tissue banking · 2022Review
- Effect of Conditioned Media of Limbal Epithelial Cells and Corneal Stromal Cells on Functional Activity of Limb Mesenchymal Stem Cells.Bulletin of experimental biology and medicine · 2022Article
- Long-Term Clinical Outcomes of Small-Incision Femtosecond Laser-Assisted Intracorneal Concave Lenticule Implantation in Patients with Keratoconus.Journal of ophthalmology · 2022Article
- Morphofunctional Properties of Corneal Stromal Cells.Bulletin of experimental biology and medicine · 2021Article
- A microscopic study of the corneal stromal lenticules extracted during femtosecond laser-assisted small incision lenticule extraction.Experimental and therapeutic medicine · 2021Article
- Corneal Stromal Regeneration: A Review of Human Clinical Studies in Keratoconus Treatment.Frontiers in medicine · 2021Review
- Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules.Journal of cellular and molecular medicine · 2021Article
- Advances in the diagnosis and treatment of keratoconus.Therapeutic advances in ophthalmologyReview
Corrections and comments
- Commented on byReply.2020
- Commented on by
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the feasibility and efficacy of small-incision femtosecond laser-assisted intracorneal concave lenticule implantation (SFII) and penetrating keratoplasty (PKP) in patients with progressive keratoconus.
methodsAll the patients were clinically diagnosed with progressive keratoconus. Twenty patients underwent PKP (PKP group), and 11 patients underwent SFII (SFII group). Visual acuity, intraocular pressure, corneal topography, corneal visualization Scheimpflug technology, anterior segment optical coherence tomography, and in vivo confocal microscopy were analyzed.
resultsVision improved at 3 months postoperatively in the SFII group. In the PKP group, corrected distance visual acuity improved 1 week after surgery. Corneal topography showed a statistically significant decrease in the anterior K1 and K2. Corneal visualization Scheimpflug technology showed that changes in the biomechanical parameters of the SFII group were also statistically different from those of the PKP group. All the grafts from both groups were clearly visible by anterior segment optical coherence tomography observation. The central corneal thickness of both groups was stable during the 24-month study period. In vivo confocal microscopy showed a few dendritic cells in the subepithelial region in the SFII group. At 3 months after surgery, many dendritic cells and inflammatory cells were observed in the basal epithelium and stroma in the PKP group.
conclusionsBoth SFII and PKP surgical procedures resulted in a stable corneal volume and improved visual acuity in this long-term study. SFII was less invasive and more efficient compared with PKP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.