ArticleJournal of neurophysiology2019
Basolateral amygdala neurons are activated during threat expectation.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Aversive 22-kHz ultrasonic vocalization playback reveals differences in affective (dys)function following early life adversity in male and female juvenile rats.Behavioural brain research · 2026Article
- Signaling of salience and prediction errors by anterior insula neurons.Biochemical and biophysical research communications · 2026Article
- Detection of latent brain states from spontaneous neural activity in the amygdala.PLoS computational biology · 2025Article
- Prefrontal projections to the bed nuclei of the stria terminalis modulate the specificity of aversive memories.Research square · 2024Article
- Detection of latent brain states from baseline neural activity in the amygdala.bioRxiv : the preprint server for biology · 2024Article
- Dynamic threat-reward neural processing under semi-naturalistic ecologically relevant scenarios.Human brain mapping · 2024Article
- Threat and Reward Imminence Processing in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala.Biological psychiatry · 2022Article
- Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma.Frontiers in systems neuroscience · 2022Review
- Article
- Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction.Scientific reports · 2021Article
- A bird's-eye view of brain activity in socially interacting mice through mobile edge computing (MEC).Science advances · 2020Article
- Distinct Processing of Aversive Experience in Amygdala Subregions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Fear conditioning studies have led to the view that the amygdala contains neurons that signal threat and in turn elicit defensive behaviors through their brain stem and hypothalamic targets. In agreement with this model, a prior unit-recording study in rats performing a seminaturalistic foraging task revealed that many lateral amygdala (LA) neurons are predator responsive. In contrast, our previous study emphasized that most basolateral (BL) amygdala neurons are inhibited at proximity of the predator. However, the two studies used different methods to analyze unit activity, complicating comparisons between them. By applying the same method to the sample of BL neurons we recorded previously, the present study revealed that most principal cells are inhibited by the predator and only 4.5% are activated. Moreover, two-thirds of these cells were also activated by nonthreatening stimuli. In fact, fitting unit activity with a generalized linear model revealed that the only task variables associated with a prevalent positive modulation of BL activity were expectation of the predator's presence and whether the prior trial had been a failure or success. At odds with the threat-coding model of the amygdala, actual confrontation with the predator was usually associated with a widespread inhibition of principal BL neurons.
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