ArticleAmerican journal of physiology. Cell physiology2019
Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining.
Article in American journal of physiology. Cell physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Myonuclear permanence in skeletal muscle memory: a systematic review and meta-analysis of human and animal studies.Journal of cachexia, sarcopenia and muscle · 2022Pooled it
- Microbial-Derived Exerkines Outperform Creatine Monohydrate in Enhancing Skeletal Muscle Adaptation to Exercise in Mice.American journal of physiology. Cell physiology · 2026Article
- Endurance exercise elicits a hepatic memory associated with improved metabolic function and protein secretion.Molecular metabolism · 2026Article
- Epigenetic Skeletal Muscle Memory: The Impact of Physical Activity on Aging and Post-Injury Regeneration.Genes · 2026Review
- Myonuclear Dynamics After Skeletal Muscle Surgical Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Exercise-associated microbial metabolites prevent skeletal muscle atrophy in adult female mice.Nature communications · 2026Article
- Exercise training prior to and during cancer in mice preserves muscle mass, reduces tumour weight and suppresses molecular mediators of cachexia.The Journal of physiology · 2026Article
- Myocellular adaptations to short-term weighted wheel-running exercise are largely conserved during C26-tumour induction in male and female mice.Experimental physiology · 2026Article
- Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle.Skeletal muscle · 2025Article
- Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle.bioRxiv : the preprint server for biology · 2025Article
- Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice.Aging cell · 2025Article
- Muscle memory of exercise optimizes mitochondrial metabolism to support skeletal muscle growth.American journal of physiology. Cell physiology · 2025Article
- The Role of Mitochondrial Dysfunction and Dynamics in Hypertensive Heart Disease: Mechanisms and Recent Advances.Biology · 2025Review
- Muscle memory theory: A critical evaluation.The Journal of physiology · 2025Article
- Animal Models of Exercise and Cardiometabolic Disease.Circulation research · 2025Review
- PoWeR elicits intracellular signaling, mitochondrial adaptations, and hypertrophy in multiple muscles consistent with endurance and resistance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- A primer on global molecular responses to exercise in skeletal muscle: Omics in focus.Journal of sport and health science · 2025Review
- Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review.Molecular medicine (Cambridge, Mass.) · 2025Review
- Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration.Skeletal muscle · 2025Article
- Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
Myonuclei gained during exercise-induced skeletal muscle hypertrophy may be long-lasting and could facilitate future muscle adaptability after deconditioning, a concept colloquially termed "muscle memory." The evidence for this is limited, mostly due to the lack of a murine exercise-training paradigm that is nonsurgical and reversible. To address this limitation, we developed a novel progressive weighted-wheel-running (PoWeR) model of murine exercise training to test whether myonuclei gained during exercise persist after detraining. We hypothesized that myonuclei acquired during training-induced hypertrophy would remain following loss of muscle mass with detraining. Singly housed female C57BL/6J mice performed 8 wk of PoWeR, while another group performed 8 wk of PoWeR followed by 12 wk of detraining. Age-matched sedentary cage-dwelling mice served as untrained controls. Eight weeks of PoWeR yielded significant plantaris muscle fiber hypertrophy, a shift to a more oxidative phenotype, and greater myonuclear density than untrained mice. After 12 wk of detraining, the plantaris muscle returned to an untrained phenotype with fewer myonuclei. A finding of fewer myonuclei simultaneously with plantaris deconditioning argues against a muscle memory mechanism mediated by elevated myonuclear density in primarily fast-twitch muscle. PoWeR is a novel, practical, and easy-to-deploy approach for eliciting robust hypertrophy in mice, and our findings can inform future research on the mechanisms underlying skeletal muscle adaptive potential and muscle memory.
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