Evidence map›Paper›PMID 30840356›Full record

ArticleChemMedChem2019

Synthesis and Biological Evaluation of RGD and isoDGR-Monomethyl Auristatin Conjugates Targeting Integrin α

André Raposo Moreira Dias, Lizeth Bodero, Ana Martins, Daniela Arosio, Silvia Gazzola, Laura Belvisi, Luca Pignataro, Christian Steinkühler, Alberto Dal Corso, Cesare Gennari and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in ChemMedChem, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Recent Advances in the Linkers of Drug Conjugates.Current medicinal chemistry · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Optimizing the enzymatic release of MMAE fromFrontiers in pharmacology · 2023
    Article
  14. Review
  15. Article
  16. Cyclic RGD andMolecules (Basel, Switzerland) · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

André Raposo Moreira DiasUniversità degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0001-6335-1156
Lizeth BoderoUniversità degli Studi dell'Insubria, Dipartimento di Scienza e Alta Tecnologia, Via Valleggio, 11, 22100, Como, Italy.ORCID 0000-0001-7459-5842
Ana MartinsExiris Srl, Via di Castel Romano, 100, 00128, Rome, Italy.
Daniela ArosioCNR, Istituto di Scienze e Tecnologie Molecolari (ISTM), Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0001-5486-3504
Silvia GazzolaUniversità degli Studi dell'Insubria, Dipartimento di Scienza e Alta Tecnologia, Via Valleggio, 11, 22100, Como, Italy.ORCID 0000-0001-6745-3598
Laura BelvisiUniversità degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0002-3593-2970
Luca PignataroUniversità degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0002-7200-9720
Christian SteinkühlerExiris Srl, Via di Castel Romano, 100, 00128, Rome, Italy.
Alberto Dal CorsoUniversità degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0003-4437-8307
Cesare GennariUniversità degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133, Milan, Italy.ORCID 0000-0002-7635-4900
Umberto PiarulliUniversità degli Studi dell'Insubria, Dipartimento di Scienza e Alta Tecnologia, Via Valleggio, 11, 22100, Como, Italy.ORCID 0000-0002-6952-1811
University of Milan · ITUniversity of Insubria · ITRINA Consulting - Centro Sviluppo Materiali S.p.A. (Italy) · ITInstitute of Molecular Science and Technologies · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work reports the synthesis of a series of small-molecule-drug conjugates containing the α

Indexed as

Antineoplastic AgentsBinding, CompetitiveCell Line, TumorCycloaddition ReactionDrug Evaluation, PreclinicalHumansIntegrin alphaVbeta3OligopeptidesAntineoplastic Agentsarginyl-glycyl-aspartic acidIntegrin alphaVbeta3monomethyl auristatin EOligopeptidesantitumor agentsauristatinsdrug deliveryintegrinspeptidomimetics

Identifiers

PMID30840356
PMCPMC6593765
OpenAlexW2922345446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.