Evidence map›Paper›PMID 30840138›Full record

ArticleJournal of materials science. Materials in medicine2019

Enhanced of antibacterial activity of antibiotic-functionalized silver nanocomposites with good biocompatibility.

Qianqian Guo, Tianyu Lan, Yi Chen, Yini Xu, Jianqing Peng, Ling Tao, Xiangchun Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Qianqian GuoThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China. guoqqsci@126.com.ORCID http://orcid.org/0000-0001-8373-3530
Tianyu LanSchool of Chemical Engineering, Guizhou Minzu University, Guiyang, Guizhou, 550025, China.
Yi ChenThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China.
Yini XuThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China.
Jianqing PengThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China.
Ling TaoThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China.
Xiangchun ShenThe Department of pharmaceutical Engineering (State Key Laboratory of Functions and Applications of Medicinal Plants, the Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang, Guizhou, 550025, China. shenxiangchun@126.com.
Guiyang Medical University · CNGuizhou Minzu University · CN

Funding

Doctoral Foundation of Guizhou Medical University JY2017-28Guizhou Provincial Department of Education Youth Science and Technology Talent Development Project [2018]150High-level Innovation Talents 2015-4029Innovated Team of the Education Department of Guizhou Province 2014-31Innovation Team of Guizhou Province 2015-4025International Science & Technology Cooperation Base (2017)5802Science and Technology Department of Guizhou Province, Guizhou Branch of Talent Gund [2017]5718
6 · The paper itself

Abstract

Antimicrobial resistance to traditional antibiotics leads to a serious concern for medical care owing to ineffective antibiotic therapies. This study focused on the preparation of silver nanocomposites (AgNPs@Tob&PAGA) by modifying AgNPs with tobramycin (Tob) and carbohydrate polymer of poly(2-(acrylamido) glucopyranose) (PAGA). The enhanced antibacterial activities of nanocomposites against common pathogens of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were explored. The introduction of PAGA onto silver nanocomposites improved both citocompatibility and antibacterial activity. Compared with nude Tob, AgNPs@Tob&PAGA showed more fascinating antimicrobial effect against E. coli and S. aureus with about 20-fold increase in the antibacterial activity, simultaneously no detectable resistance was observed. Consequently, the silver nanocomposite as an antimicrobial agent presents promising prospects in the treatment of bacterial infections caused by antimicrobial resistant bacteria.

Indexed as

Drug Resistance, BacterialAnimalsAnti-Bacterial AgentsBiocompatible MaterialsCarbohydratesCell SurvivalEscherichia coliGraphiteHumansHuman Umbilical Vein Endothelial CellsMetal NanoparticlesMiceMicrobial Sensitivity TestsNanocompositesNIH 3T3 CellsPolyglycolic AcidAnti-Bacterial AgentsBiocompatible MaterialsCarbohydratesGraphitepoly((4-aminobutyl)glycolic acid)Polyglycolic AcidSilverTobramycin

Identifiers

PMID30840138
OpenAlexW2921401724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.