Evidence map›Paper›PMID 30840126›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2019

Microvascular density and hypoxia-inducible factor in intraepithelial vocal fold lesions.

Anna Rzepakowska, Michał Żurek, Jakub Grzybowski, Paweł Pihowicz, Barbara Górnicka, Kazimierz Niemczyk, Ewa Osuch-Wójcikiewicz

Open access · hybridAbstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anna RzepakowskaOtolaryngology Department, Medical University of Warsaw, Warsaw, Poland.
Michał ŻurekStudents Scientific Research Group by Otolaryngology Department, Medical University of Warsaw, Warsaw, Poland.
Jakub GrzybowskiDepartment of Pathology, Medical University of Warsaw, 7, Pawińskiego Str., 02-004, Warsaw, Poland. jgrzybowski@wum.edu.pl.ORCID http://orcid.org/0000-0001-5549-2266
Paweł PihowiczDepartment of Pathology, Medical University of Warsaw, 7, Pawińskiego Str., 02-004, Warsaw, Poland.
Barbara GórnickaDepartment of Pathology, Medical University of Warsaw, 7, Pawińskiego Str., 02-004, Warsaw, Poland.
Kazimierz NiemczykOtolaryngology Department, Medical University of Warsaw, Warsaw, Poland.
Ewa Osuch-WójcikiewiczOtolaryngology Department, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe promotion of neovascularisation is a crucial aspect of carcinogenesis. The study evaluates the microvascular density (MVD) and expression of hypoxia-induced factor (HIF-1α) in hypertrophic vocal fold (VF) lesions of different histopathological states including non-dysplastic, low-grade, high-grade dysplasia and invasive glottic cancer. MATERIALS AND

methodsHistological specimens collected from patients diagnosed and treated in a single centre with different histological grades were immunohistochemically stained with CD31, CD34 and HIF-1α. Of the total number of 77 analysed VF specimens, 20 were non-dysplastic, 20 had low-grade dysplasia, 17 high-grade dysplasia and 20 were invasive cancers.

resultsThe highest mean value for MVD evaluated with expression of CD31 (MVD CD31) was 21.23 ± 14.46 and identified in the low-grade dysplasia group. The average MVD CD31 was 13.74 ± 5.56 and 20.11 ± 9.28 in the high-grade dysplasia and invasive cancer group, respectively. The highest MVD evaluated with CD34 (MVD CD34) was revealed for invasive cancer 35.64 ± 17.21. The MVD CD34 was higher for low-grade than in high-grade dysplasia (25.87 ± 12.30 vs 24.65 ± 15.92, respectively). The expression of HIF-1α was strong or very strong in 60% of non-dysplastic lesions, 100% of low-grade dysplasia cases, 53% of high-grade dysplasia cases and 50% of invasive cancer cases. The comparison of MVD CD31 with MVD CD34 revealed a strong positive correlation (ρ value 0.727). The comparison of both MVD CD31 and MVD CD34 with HIF-1α resulted in no linear relationship (ρ value of 0.143 and 0.165, respectively).

conclusionThe stage of low-grade dysplasia in intraepithelial vocal fold lesions is related to significant advancement of angiogenesis together with the highest hypoxia level.

Indexed as

HypoxiaMicrovesselsNeovascularization, PathologicVocal CordsAdultAgedCarcinogenesisCorrelation of DataFemaleHumansHypertrophyHypoxia-Inducible Factor 1, alpha SubunitLaryngeal NeoplasmsMaleMiddle AgedNeoplasm GradingHypoxia-Inducible Factor 1, alpha SubunitAngiogenesisDysplasiaGlottic cancerHypoxiaIntraepithelial lesionsLarynxMicrovascular density

Identifiers

PMID30840126
PMCPMC6426810
OpenAlexW2918590777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.