Evidence map›Paper›PMID 30840115›Full record

ReviewWorld journal of urology2020

Perioperative venous thromboembolism prophylaxis in prostate cancer surgery.

Zachary Klaassen, Christopher J D Wallis, Luke T Lavallée, Philippe D Violette

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  14. Thromboembolic Events after Surgery for Localized Prostate Cancer: Incidence, Risk Factors, and Survival Outcomes.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Zachary KlaassenDivision of Urology, Department of Surgery, Medical College of Georgia At Augusta University, Augusta, GA, USA.
Christopher J D WallisDivision of Urology, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Luke T LavalléeDivision of Urology, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Philippe D VioletteDivision of Urology, Department of Surgery, Woodstock General Hospital, Woodstock, ON, Canada. philippedenis.violette@gmail.com.ORCID http://orcid.org/0000-0002-6116-5496
Augusta University · USCentegra Hospital Woodstock · USUniversity of Ottawa · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe a patient and procedure specific approach to selecting Venous thromboembolism (VTE) prophylaxis for men who undergo radical prostatectomy.

methodsWe performed a literature search and narrative review of VTE after radical prostatectomy. We describe the current paradigm of perioperative thromboprophylaxis and underlying rationale. Relevant findings from the European Association of Urology thromboprophylaxis guidelines are interpreted and summarized.

resultsThe use of extended post-operative thromboprophylaxis for patients who undergo radical prostatectomy is appropriate when the risk of symptomatic VTE outweighs the risk of major bleeding. Patient and procedure factors impact VTE risk. Patient risk can be stratified as low, moderate or high based on 4 factors; age > 75, BMI > 35, VTE in a first degree relative, and personal history of VTE. Procedure risk of VTE and bleeding can be stratified by modality of surgery (open, laparoscopic, robotic) and extent of pelvic lymphadenectomy. Using these factors, patients at the lowest risk for VTE will have an expected incidence of VTE of 0.4-0.8% and those at highest risk from 1.5 to 15.7%. Incidence of major bleeding ranges from 0.4 to 1.4%. These ranges emphasize the need to consider the net benefit for each specific patient. Use of mechanical prophylaxis is supported by weaker evidence but has fewer harms and is likely reasonable for most patients.

conclusionMany patients who undergo radical prostatectomy will benefit from extended post-operative thromboprophylaxis. Risk of thrombosis is likely higher with open approach and extended lymph node dissection. The net benefit of treatment should be considered using patient- and procedure-specific criteria. When the net benefit is negligible or possibly harmful no pharmacological thromboprophylaxis should be used.

Indexed as

Lymph Node ExcisionProstatectomyStockings, CompressionAnticoagulantsDuration of TherapyEvidence-Based MedicineHeparinHumansLaparoscopyMalePelvisPerioperative CarePostoperative ComplicationsPostoperative HemorrhagePractice Guidelines as TopicProstatic NeoplasmsAnticoagulantsHeparinExtended prophylaxisProstate cancerRadical prostatectomyRobotic prostatectomyVenous thromboembolism

Identifiers

PMID30840115
OpenAlexW2920937643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.