Evidence map›Paper›PMID 30840108›Full record

ArticleDer Anaesthesist2019

[Neurobiology of opioid dependence].

N Scherbaum, U Bonnet

Abstract read
PubMed Publisher
In one paragraph

Article in Der Anaesthesist, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

N ScherbaumKlinik für Abhängiges Verhalten und Suchtmedizin, LVR-Klinikum Essen, Kliniken der Universität Duisburg-Essen, Virchowstr. 174, 45147, Essen, Deutschland. norbert.scherbaum@uni-due.de.
U BonnetKlinik für Abhängiges Verhalten und Suchtmedizin, LVR-Klinikum Essen, Kliniken der Universität Duisburg-Essen, Virchowstr. 174, 45147, Essen, Deutschland.
Rütgers (Germany) · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid dependence is a chronic mental disease with multifactorial etiology. The neurobiological theory of addiction focuses on the manipulation of the dopaminergic reward system as a basic property of substances with addictive potential including opioids. With regular opioid intake, the manipulation of the reward system results in a cognitive bias towards drug-related stimuli. In addition, opioids inhibit the locus caeruleus, resulting in symptoms of sympathetic rebound during opioid detoxification. The pharmacokinetics of opioids also influence the risk of addiction. These biological factors are independent of the legal status of the individual opioid. Genetics also significantly influence the etiology. However, the assignment of this genetic influence is difficult because not only basic biological functions, but also personality traits and mental illnesses are genetically determined.

Indexed as

Analgesics, OpioidHumansOpioid-Related DisordersRewardAnalgesics, OpioidGenetic predisposition, opioid addictionLocus caeruleusPharmacokinetics, opioidsPsychosocial factorsReward, dopaminergic

Identifiers

PMID30840108
OpenAlexW2922370673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.