ArticleJournal of experimental botany2019
Cit1,2RhaT and two novel CitdGlcTs participate in flavor-related flavonoid metabolism during citrus fruit development.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Metabolomics Reveals the Dynamic Characteristics of Flavonoids During the Different Developmental Stages ofCurrent issues in molecular biology · 2026Article
- Integrated transcriptomic and metabolomic analyses identify OsCGT as essential for C-glycosyl flavone biosynthesis in OsDET1-mutant rice seeds.BMC plant biology · 2026Article
- Evolutionary origin of neohesperidoside, a bitter metabolite, and its potential role in biotic defense and citrus dissemination.Plant communications · 2026Article
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- Flavonoids: biological activities, nutritional and immunological aspects, therapeutic potential, food applications, and human health benefits-A comprehensive review.Frontiers in nutrition · 2026Review
- Haplotype-resolved genome of a papeda provides insights into the geographical origin and evolution of Citrus.Journal of integrative plant biology · 2025Article
- Updated Gene Prediction of the Cucumber (9930) Genome through Manual Annotation.Plants (Basel, Switzerland) · 2024Article
- Four novelHorticulture research · 2024Article
- Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in abiotic stress and flavonol biosynthesis in Nicotiana tabacum.BMC plant biology · 2023Article
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- Comparative transcriptomics of wild and commercial Citrus during early ripening reveals how domestication shaped fruit gene expression.BMC plant biology · 2022Article
- Characterization of pectin methylesterase gene family and its possible role in juice sac granulation in navel orange (Citrus sinensis Osbeck).BMC genomics · 2022Article
- Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes.Antioxidants (Basel, Switzerland) · 2022Review
- Illustration of the variation in the content of flavanone rutinosides in various citrus germplasms from genetic and enzymatic perspectives.Horticulture research · 2022Article
- The high-quality genome of pummelo provides insights into the tissue-specific regulation of citric acid and anthocyanin during domestication.Horticulture research · 2022Article
- Antioxidative, cytoprotective and whitening activities of fragrant pear fruits at different growth stages.Frontiers in nutrition · 2022Article
- Comparative Analysis of Flavonoid Metabolites in Foxtail Millet (Life (Basel, Switzerland) · 2021Article
- Multiomics-based dissection of citrus flavonoid metabolism using a Citrus reticulata × Poncirus trifoliata population.Horticulture research · 2021Article
- Genomic insights into citrus domestication and its important agronomic traits.Plant communications · 2021Review
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neohesperidosides are disaccharides that are present in some flavonoids and impart a bitter taste, which can significantly affect the commercial value of citrus fruits. In this study, we identified three flavonoid-7-O-di-glucosyltransferase (dGlcT) genes closely related to 1,2-rhamnosyltransferase (1,2RhaT) in citrus genomes. However, only 1,2RhaT was directly linked to the accumulation of neohesperidoside, as demonstrated by association analysis of 50 accessions and co-segregation analysis of an F1 population derived from Citrus reticulata × Poncirus trifoliata. In transgenic tobacco BY2 cells, over-expression of CitdGlcTs resulted in flavonoid-7-O-glucosides being catalysed into bitterless flavonoid-7-O-di-glucosides, whereas over-expression of Cit1,2RhaT converted the same substrate into bitter-tasting flavonoid-7-O-neohesperidoside. Unlike 1,2RhaT, during citrus fruit development the dGlcTs showed an opposite expression pattern to CHS and CHI, two genes encoding rate-limiting enzymes of flavonoid biosynthesis. An uncoupled availability of dGlcTs and substrates might result in trace accumulation of flavonoid-7-O-di-glucosides in the fruit of C. maxima (pummelo). Past human selection of the deletion and functional mutation of 1,2RhaT has led step-by-step to the evolution of the flavor-related metabolic network in citrus. Our research provides the basis for potentially improving the taste in citrus fruit through manipulation of the network by knocking-out 1,2RhaT or by enhancing the expression of dGlcT using genetic transformation.
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