ArticleHeliyon2019
Effects of high temperature on pandemic and seasonal human influenza viral replication and infection-induced damage in primary human tracheal epithelial cell cultures.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Rhinothermy delivered by nasal high flow therapy in the treatment of the common cold: a randomised controlled trial.BMJ open · 2021Trial
- Nasopharyngeal Airspace Temperature During Rhinothermy.Respiratory care · 2025Article
- Nasopharyngeal Airspace Temperature During Rhinothermy.Respiratory care · 2025Article
- Temperature affects reptarenavirus growth in a permissive host-derivedThe Journal of general virology · 2025Article
- Review
- Article
- COVID-19 and Cancer Diseases-The Potential ofInternational journal of molecular sciences · 2023Review
- Review
- Fever as an evolutionary agent to select immune complexes interfaces.Immunogenetics · 2022Article
- Understanding the Variability of Certain Biological Properties of H1N1pdm09 Influenza Viruses.Vaccines · 2022Article
- Associations between Temperature and Influenza Activity: A National Time Series Study in China.International journal of environmental research and public health · 2021Article
- The role of respiratory droplet physicochemistry in limiting and promoting the airborne transmission of human coronaviruses: A critical review.Environmental pollution (Barking, Essex : 1987) · 2021Review
- Effect of a fever in viral infections - the 'Goldilocks' phenomenon?World journal of clinical cases · 2021Review
- Polymers in the Medical Antiviral Front-Line.Polymers · 2020Review
- Overview of seasonal influenza and recommended vaccine during the 2016/2017 season in Nepal.Heliyon · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High temperature reduces influenza viral replication; however, the treatment of fevers is thought to be necessary to improve patients' conditions. We examined the effects of high temperature on viral replication and infection-induced damage to human tracheal epithelial cells. Cell viability and dome formation were reduced, the number of detached cells was increased and lactate dehydrogenase (LDH) levels tended to be increased from 72 h to 120 h in uninfected cells cultured at 40 °C. Long-term (72 h and/or 120 h) exposure to high temperatures (39 °C and/or 40 °C) decreased RNA levels and/or viral titers of eight influenza virus strains. Cell viability and dome formation were reduced, and the number of detached cells and LDH levels were increased to a similar extent after infection with the A/H1N1 pdm 2009 virus at 37 °C and 40 °C. High temperature increased the endosomal pH, where the viral RNA enters the cytoplasm, in uninfected cells. High temperature reduced the production of IL-6, which mediate viral replication processes, and IL-1β and IL-8 in uninfected and infected cells. Based on these findings, high temperature may cause similar levels of airway cell damage after infection to cells exposed normal temperatures, although high temperature reduces viral replication by affecting the function of acidic endosomes and inhibiting IL-6-mediated processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.