ArticleRoyal Society open science2018
Halloween genes in panarthropods and the evolution of the early moulting pathway in Ecdysozoa.
Article in Royal Society open science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Neuropeptide F alters expression of feeding, energy metabolism, and reproduction genes in female freshwater prawn, Macrobrachium rosenbergii.Scientific reports · 2026Article
- Molting in Pancrustacea Is Characterized by Both Deeply Conserved and Recently Evolved Gene Modules.Genome biology and evolution · 2026Article
- RNAi-Mediated Knockdown of Halloween Genes in Lygus hesperus Has Varied Effects on Oogenesis and Fertility.Archives of insect biochemistry and physiology · 2026Article
- Genetic and Molecular Regulation of Ecdysone Biosynthesis During Insect Metamorphosis.Insects · 2026Review
- Evolutionary dynamics of the arthropod molting machinery.Molecular biology and evolution · 2026Review
- Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation.Molecular biology and evolution · 2026Article
- What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Properties of "Stable" Mosquito Cytochrome P450 Enzymes.Insects · 2025Article
- Molting in early Cambrian armored lobopodians.Communications biology · 2024Article
- Article
- Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem?The FEBS journal · 2024Review
- Storage cell proliferation during somatic growth establishes that tardigrades are not eutelic organisms.Biology open · 2024Article
- Ontogeny of the Cytochrome P450 Superfamily in the Ornate Spiny Lobster (International journal of molecular sciences · 2024Article
- Ecdysteroid Biosynthesis Halloween GeneInternational journal of molecular sciences · 2023Article
- Expanding on Our Knowledge of Ecdysozoan Genomes: A Contiguous Assembly of the Meiofaunal Priapulan Tubiluchus corallicola.Genome biology and evolution · 2023Article
- A multiscale approach reveals elaborate circulatory system and intermittent heartbeat in velvet worms (Onychophora).Communications biology · 2023Article
- Article
- RNAi-Mediated Silencing of Putative Halloween Gene Phantom Affects the Performance of Rice Striped Stem Borer,Insects · 2022Article
- Transcriptional Regulators of Ecdysteroid Biosynthetic Enzymes and Their Roles in Insect Development.Frontiers in physiology · 2022Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moulting is a characteristic feature of Ecdysozoa-the clade of moulting animals that includes the hyperdiverse arthropods and less speciose groups, such as onychophorans, tardigrades and nematodes. Moulting has been best analysed in arthropods, specifically in insects and crustaceans, in which a complex neuroendocrine system acts at the genomic level and initiates the transcription of genes responsible for moulting. The key moulting hormones, ecdysone and 20-hydroxyecdysone, are subsequently synthesized from cholesterol ingested with food. Their biosynthesis is regulated by the Rieske-domain protein Neverland and cytochrome P450 enzymes encoded by the so-called 'Halloween' genes. Ecdysone is then released into the haemolymph and modified into 20-hydroxyecdysone, which binds to the nuclear receptor EcR/USP and initiates transcription of the Early genes. As little is known about the moulting pathway of other ecdysozoans, we examined the occurrence of genes involved in ecdysteroid biosynthesis and the early moulting cascade across ecdysozoan subgroups. Genomic and transcriptomic searches revealed no Halloween genes in cycloneuralians, whereas only
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.