ArticleLight, science & applications2018
Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography.
Article in Light, science & applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Review
- Devices and Methods for Dosimetry of Personalized Photodynamic Therapy of Tumors: A Review on Recent Trends.Cancers · 2024Review
- Label-free concurrent 5-modal microscopy (Co5M) resolves unknown spatio-temporal processes in wound healing.Communications biology · 2021Article
- Origins of subdiffractional contrast in optical coherence tomography.Biomedical optics express · 2021Article
- Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography.Scientific reports · 2021Article
- Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography.Biomedical optics express · 2021Article
- Article
- Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina.Biomedical optics express · 2020Article
- Imaging oxygenation of retinal capillaries with depth resolution.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Retinal capillary oximetry with visible light optical coherence tomography.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring.Scientific reports · 2019Article
- Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography.Neurophotonics · 2019Article
- Quantitative quality-control metrics forBiomedical optics express · 2019Article
- Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging.Light, science & applications · 2019Article
- Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification.Light, science & applications · 2019Article
- Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms. However, capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo. Here we demonstrate a novel optical imaging system, dual-band dual-scan inverse spectroscopic optical coherence tomography (D2-ISOCT), that, for the first time, can simultaneously obtain the following metrics in vivo using endogenous contrast: (1) capillary-level oxygen saturation and arteriolar-level blood flow rates, oxygen delivery rates, and oxygen metabolic rates; (2) spatial characteristics of tissue structures at length scales down to 30 nm; and (3) morphological images up to 2 mm in depth. To illustrate the capabilities of D2-ISOCT, we monitored alterations to capillaries and the surrounding pericapillary tissue (tissue between the capillaries) in the healing response of a mouse ear wound model. The obtained microvascular and ultrastructural metrics corroborated well with each other, showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.