ArticleLight, science & applications2018
Multispectral light scattering endoscopic imaging of esophageal precancer.
Article in Light, science & applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- LED-based, real-time, hyperspectral imaging device.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Multimodal esophageal cancer imaging: establishing data processing techniques and assessing diagnostic sensitivity.Biophotonics discovery · 2025Article
- Cancer characterization using light backscattering spectroscopy and quantitative ultrasound: an ex vivo study on sarcoma subtypes.Scientific reports · 2023Article
- Surgical polarimetric endoscopy for the detection of laryngeal cancer.Nature biomedical engineering · 2023Article
- A high-precision multi-dimensional microspectroscopic technique for morphological and properties analysis of cancer cell.Light, science & applications · 2023Article
- Solid Particle Swarm Measurement in Jet Fuel Based on Mie Scattering Theory and Extinction Method.Sensors (Basel, Switzerland) · 2023Article
- Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope.Digestive diseases and sciences · 2022Article
- Spectral Endoscopy Enhances Contrast for Neoplasia in Surveillance of Barrett's Esophagus.Cancer research · 2021Article
- Silica optical fiber integrated with two-dimensional materials: towards opto-electro-mechanical technology.Light, science & applications · 2021Review
- Novel endoscopic optical diagnostic technologies in medical trial research: recent advancements and future prospects.Biomedical engineering online · 2021Review
- Quantitative phase and polarization imaging through an optical fiber applied to detection of early esophageal tumorigenesis.Journal of biomedical optics · 2019Article
- A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract.Nature communications · 2019Article
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Spectroscopy for Esophageal Diseases.Gastroenterology & hepatology · 2018Article
- Molecular endoscopic imaging: the future is bright.Therapeutic advances in gastrointestinal endoscopyReview
- Multispectral Endoscopy with Light Gating for Early Cancer Detection.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Esophageal adenocarcinoma is the most rapidly growing cancer in America. Although the prognosis after diagnosis is unfavorable, the chance of a successful outcome increases tremendously if detected early while the lesion is still dysplastic. Unfortunately, the present standard-of-care, endoscopic surveillance, has major limitations, since dysplasia is invisible, often focal, and systematic biopsies typically sample less than one percent of the esophageal lining and therefore easily miss malignancies. To solve this problem we developed a multispectral light scattering endoscopic imaging system. It surveys the entire esophageal lining and accurately detects subcellular dysplastic changes. The system combines light scattering spectroscopy, which detects and identifies invisible dysplastic sites by analyzing light scattered from epithelial cells, with rapid scanning of the entire esophageal lining using a collimated broadband light beam delivered by an endoscopically compatible fiber optic probe. Here we report the results of the first comprehensive multispectral imaging study, conducted as part of routine endoscopic procedures performed on patients with suspected dysplasia. In a double-blind study that characterized the system's ability to serve as a screening tool, 55 out of 57 patients were diagnosed correctly. In addition, a smaller double-blind comparison of the multispectral data in 24 patients with subsequent pathology at locations where 411 biopsies were collected yielded an accuracy of 90% in detecting individual locations of dysplasia, demonstrating the capability of this method to serve as a guide for biopsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.