Evidence map›Paper›PMID 30839203›Full record

ArticleBiochemistry2019

A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β.

Keriann Oertell, Jan Florián, Pouya Haratipour, Debbie C Crans, Boris A Kashemirov, Samuel H Wilson, Charles E McKenna, Myron F Goodman

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polλ promotes microhomology-mediated end-joining.Nature structural & molecular biology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Keriann OertellDepartment of Biological Sciences, Dana and David Dornsife College of Letters, Arts, and Sciences , University of Southern California , University Park Campus , Los Angeles , California 90089 , United States.
Jan FloriánDepartment of Chemistry and Biochemistry , Loyola University Chicago , 1032 West Sheridan Road , Chicago , Illinois 60660 , United States.ORCID 0000-0003-2669-4293
Pouya HaratipourDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences , University of Southern California , University Park Campus , Los Angeles , California 90089 , United States.ORCID 0000-0003-0181-8958
Debbie C CransDepartment of Chemistry , Colorado State University , Fort Collins , Colorado 80523 , United States.ORCID 0000-0001-7792-3450
Boris A KashemirovDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences , University of Southern California , University Park Campus , Los Angeles , California 90089 , United States.
Samuel H WilsonGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences , National Institutes of Health , Research Triangle Park , North Carolina 27709 , United States.ORCID 0000-0002-1702-5293
Charles E McKennaDepartment of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences , University of Southern California , University Park Campus , Los Angeles , California 90089 , United States.ORCID 0000-0002-3540-6663
Myron F GoodmanDepartment of Biological Sciences, Dana and David Dornsife College of Letters, Arts, and Sciences , University of Southern California , University Park Campus , Los Angeles , California 90089 , United States.ORCID 0000-0001-9601-3284
University of Southern California · USColorado State University · USLoyola University Chicago · USNational Institutes of Health · US

Funding

Biology of Mammalian Base Excision Repair and HIV-1 ReplicationZIAES050159 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILSON, SAMUEL H · 2009 to 2022
$29.7M
Mechanisms of Nucleic Acid Enzymes - Pol Beta, HIV-1 Reverse Transcriptase and Mammalian Base Repair EnzymesZIAES050158 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILSON, SAMUEL H · 2009 to 2022
$17.0M
Molecular Mechanisms of Human DNA Polymerase Beta Catalysis, Fidelity and Selective InhibitionU19CA177547 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODMAN, MYRON · 2013 to 2017
$5.5M
BIOLOGY OF MAMMALIAN BASE EXCISION REPAIRZ01ES050159 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILSON, SAMUEL H · 1997 to 2008
$4.5M
Nucleic Acid Enzymes--Pol Beta And Base Repair EnzymesZ01ES050158 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WILSON, SAMUEL H · 1997 to 2008
$2.8M
Intramural NIH HHS Z01 ES050158Intramural NIH HHS Z01 ES050159NCI NIH HHS U19 CA177547NIEHS NIH HHS Z01 ES050158NIEHS NIH HHS Z01 ES050159
6 · The paper itself

Abstract

Deoxynucleotide misincorporation efficiencies can span a wide 10

Indexed as

Base PairingCatalytic DomainDeoxyadenine NucleotidesDeoxyguanine NucleotidesDNA-Directed DNA PolymeraseDNA Polymerase betaDNA Polymerase gammaHumansKineticsSubstrate SpecificityThermodynamicsY-Family DNA Polymerases2'-deoxyadenosine-3'-triphosphateDeoxyadenine NucleotidesDeoxyguanine Nucleotidesdeoxyguanosine triphosphateDNA-Directed DNA PolymeraseDNA Polymerase betaDNA Polymerase gammaRad30 proteinY-Family DNA Polymerases

Identifiers

PMID30839203
PMCPMC6681824
OpenAlexW2921804432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.