Evidence map›Paper›PMID 30838875›Full record

ReviewAmerican journal of physiology. Renal physiology2019

Paracellular calcium transport in the proximal tubule and the formation of kidney stones.

Joshua N Curry, Alan S L Yu

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. CompoundAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2024
    Article
  5. Review
  6. Article
  7. Claudins in kidney health and disease.Kidney research and clinical practice · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua N CurryDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center , Kansas City, Kansas.ORCID 0000-0002-7364-964X
Alan S L YuJared Grantham Kidney Institute, University of Kansas Medical Center , Kansas City, Kansas.ORCID 0000-0002-1776-2533
University of Kansas Medical Center · US

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ANDREW K. GODWIN · 2019 to 2026
$21.5M
Role of Claudin-2 in Calcium Homeostasis and Kidney Stone DiseaseR01DK115727 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Alan S Yu · 2019 to 2026
$2.5M
The role of claudin-2 in proximal tubule calcium reabsorptionF30DK109605 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CURRY, JOSHUA · 2016 to 2019
$171k
NIDDK NIH HHS F30 DK109605NIDDK NIH HHS R01 DK115727NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

The proximal tubule (PT) is responsible for the majority of calcium reabsorption by the kidney. Most PT calcium transport appears to be passive, although the molecular facilitators have not been well established. Emerging evidence supports a major role for PT calcium transport in idiopathic hypercalciuria and the development of kidney stones. This review will cover recent developments in our understanding of PT calcium transport and the role of the PT in kidney stone formation.

Indexed as

Renal ReabsorptionAnimalsCalciumClaudinsHumansHypercalciuriaIon TransportKidney CalculiKidney Tubules, ProximalMembrane Transport ProteinsNephrocalcinosisCalciumClaudinsCLDN2 protein, humanMembrane Transport Proteinscalciumhypercalciuriakidney stonesnephrocalcinosisproximal tubule

Identifiers

PMID30838875
PMCPMC6580246
OpenAlexW2920859570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.