Evidence map›Paper›PMID 30838871›Full record

ReviewAmerican journal of physiology. Renal physiology2019

Potassium-sparing effects of furosemide in mice on high-potassium diets.

Bangchen Wang, Steven C Sansom

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bangchen WangDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center , Omaha, Nebraska.
Steven C SansomDepartment of Cellular and Integrative Physiology, University of Nebraska Medical Center , Omaha, Nebraska.
University of Nebraska Medical Center · US

Funding

Role of BK-Beta 1 in flow-dependent K+ secretion in the CNTR01DK071014 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SANSOM, STEVEN · 2007 to 2015
$2.7M
Role of BK-alpha/beta 4 in renal secretionR01DK092474 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SANSOM, STEVEN · 2011 to 2015
$1.6M
Net K Secretion in Thick Ascending Limb of Mice on Low Na High K DietF30DK108456 · NIDDK · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, BANGCHEN · 2015 to 2019
$190k
NIDDK NIH HHS F30 DK108456NIDDK NIH HHS R01 DK071014NIDDK NIH HHS R01 DK092474
6 · The paper itself

Abstract

In individuals on a regular "Western" diet, furosemide induces a kaliuresis and reduction in plasma K concentration by inhibiting Na reabsorption in the thick ascending limb of Henle's loop, enhancing delivery of Na to the aldosterone-sensitive distal nephron. In the aldosterone-sensitive distal nephron, the increased Na delivery stimulates K wasting due to an exaggerated exchange of epithelial Na channel-mediated Na reabsorption of secreted K. The effects of furosemide are different in mice fed a high-K, alkaline (HK) diet: the large-conductance Ca-activated K (BK) channel, in conjunction with the BK β

Indexed as

AnimalsDiuretics, Potassium SparingFurosemideKidneyLarge-Conductance Calcium-Activated Potassium ChannelsMicePotassium Channels, Inwardly RectifyingPotassium, DietaryRenal EliminationDiuretics, Potassium SparingFurosemideKcnj1 protein, mouseLarge-Conductance Calcium-Activated Potassium ChannelsPotassium Channels, Inwardly RectifyingPotassium, DietaryBKfurosemidehigh-K dietROMK

Identifiers

PMID30838871
PMCPMC6580254
OpenAlexW2921274485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.