Evidence map›Paper›PMID 30838786›Full record

ArticlePigment cell & melanoma research2019

SOX10 regulates multiple genes to direct eumelanin versus pheomelanin production in domestic rock pigeon.

Eric T Domyan, Jeremy Hardy, Tanner Wright, Cody Frazer, Jordan Daniels, Joshua Kirkpatrick, Jacob Kirkpatrick, Kazumasa Wakamatsu, Jonathon T Hill

Open access · hybridAbstract read
In one paragraph

Article in Pigment cell & melanoma research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Eric T DomyanDepartment of Biology, Utah Valley University, Orem, Utah.ORCID 0000-0003-2837-0436
Jeremy HardyDepartment of Biology, Utah Valley University, Orem, Utah.
Tanner WrightDepartment of Biology, Utah Valley University, Orem, Utah.
Cody FrazerDepartment of Biology, Utah Valley University, Orem, Utah.
Jordan DanielsDepartment of Biology, Utah Valley University, Orem, Utah.
Joshua KirkpatrickDepartment of Biology, Utah Valley University, Orem, Utah.
Jacob KirkpatrickDepartment of Biology, Utah Valley University, Orem, Utah.
Kazumasa WakamatsuDepartment of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan.ORCID 0000-0003-1748-9001
Jonathon T HillDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, Utah.
Utah Valley University · USBrigham Young University · USFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The domesticated rock pigeon (Columba livia) has been bred for hundreds of years to display an immense variety of ornamental attributes such as feather color and color patterns. Color is influenced by multiple loci that impact the type and amount of melanin deposited on the feathers. Pigeons homozygous for the "recessive red" mutation, which causes downregulation of Sox10, display brilliant red feathers instead of blue/black feathers. Sox10 encodes a transcription factor important for melanocyte differentiation and function, but the genes that mediate its promotion of black versus red pigment are unknown. Here, we present a transcriptomic comparison of regenerating feathers from wild-type and recessive red pigeons to identify candidate SOX10 targets. Our results identify both known and novel targets, including many genes not previously implicated in pigmentation. These data highlight the value of using novel, emerging model organisms to gain insight into the genetic basis of pigment variation.

Indexed as

AnimalsAnimals, DomesticAvian ProteinsColumbidaeFeathersFemaleMaleMelaninsMiceMice, KnockoutMutationPhenotypeSOXE Transcription FactorsAvian ProteinseumelaninMelaninspheomelaninSox10 protein, mouseSOXE Transcription Factorsdifferential gene expressionmelanogenesispigeonRNA-seqSox10

Identifiers

PMID30838786
PMCPMC6850303
OpenAlexW2922370502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.