ArticleDepression and anxiety2019
Explaining the association between anxiety disorders and alcohol use disorder: A twin study.
Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Are online norms-based alcohol interventions efficacious for college students with higher social anxiety?Alcohol, clinical & experimental research · 2025Trial
- Comparative effects of topiramate and naltrexone on neural activity during anticipatory anxiety in individuals with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- Protective behavioral strategies underutilization mediates effect of a brief motivational intervention among socially anxious undergraduate drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021Trial
- Alcohol use among adolescents in eight sub-Saharan African countries: evidence from the Global School-based student health survey (2012-2017) using the socio-ecological model.BMC psychiatry · 2025Article
- Exploring the Relationship Between Behavioral Inhibition and Approach Systems and Alcohol-Related Outcomes in People With Alcohol Use Disorder.Brain and behavior · 2025Article
- Validation of the Alcohol Use Questionnaire (AUQ) in the Italian Context: A Measure for Assessing Alcohol Intake and Binge Drinking.European journal of investigation in health, psychology and education · 2025Article
- Are Depressive and Anxiety Symptoms Differentially Associated with Alcohol Use Behaviors: Multivariate Behavioral Genetic Analyses.Behavior genetics · 2025Article
- The Correlation Between Emotionality Changes and Alcohol Consumption in Young Persons: A Pilot Study.Healthcare (Basel, Switzerland) · 2025Article
- Insights into Overlapping Brain Networks for Anxiety and Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Chronic Low Back Pain Causal Risk Factors Identified by Mendelian Randomization: a Cross-Sectional Cohort Analysis.medRxiv : the preprint server for health sciences · 2024Article
- Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.Psychological medicine · 2024Article
- Relationship Between Father-Child Attachment and Adolescents' Anxiety: The Bidirectional Chain Mediating Roles of Neuroticism and Peer Attachment.Psychology research and behavior management · 2024Article
- "Close your eyes and relax": the role of hypnosis in reducing anxiety, and its implications for the prevention of cardiovascular diseases.Frontiers in psychology · 2024Review
- The relationship of school performance with self-control and grit is strongly genetic and weakly causal.NPJ science of learning · 2023Article
- Recent advances in the understanding and psychological treatment of social anxiety disorder.Faculty reviews · 2023Review
- Psychological Distress, Obsessive Compulsive Thoughts about Drinking, and Alcohol Consumption in Young Adult Drinkers.Journal of substance use · 2022Article
- Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Twins and Causal Inference: Leveraging Nature's Experiment.Cold Spring Harbor perspectives in medicine · 2021Review
- Anxiety and Stress-Related Disorders.Focus (American Psychiatric Publishing) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIt is unknown whether social anxiety disorder (SAD) has a unique association with alcohol use disorder (AUD) over and beyond that of other anxiety disorders, how the associations develop over time, and whether the associations are likely to be causal.
methodsDiagnoses of AUD, SAD, generalized anxiety disorder, panic disorder, agoraphobia, and specific phobias were assessed twice using the Composite International Diagnostic Interview among 2,801 adult Norwegian twins. The data were analyzed using logistic regression analyses and multivariate biometric structural equation modeling.
resultsSAD had the strongest association with AUD, and SAD predicted AUD over and above the effect of other anxiety disorders. In addition, SAD was prospectively associated with AUD, whereas other anxiety disorders were not. AUD was associated with a slightly elevated risk of later anxiety disorders other than SAD. Biometric modeling favored a model where SAD influenced AUD compared to models where the relationship was reversed or due to correlated risk factors. Positive associations between AUD and other anxiety disorders were fully explained by shared genetic risk factors.
conclusionsUnlike other anxiety disorders, SAD plausibly has a direct effect on AUD. Interventions aimed at prevention or treatment of SAD may have an additional beneficial effect of preventing AUD, whereas interventions aimed at other anxiety disorders are unlikely to have a similar sequential effect on AUD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.