ArticleRespirology (Carlton, Vic.)2019
Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.
Article in Respirology (Carlton, Vic.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Article
- Obesity, Inflammation, and Severe Asthma: an Update.Current allergy and asthma reports · 2021Review
- Linggan Wuwei Jiangxin formula ameliorates airway hyperresponsiveness through suppression of IL-1β and IL-17A expression in allergic asthmatic mice especially with diet-induced obesity.Annals of translational medicine · 2021Article
- Area Under the Expiratory Flow-Volume Curve (AEX): Assessing Bronchodilator Responsiveness.Lung · 2020Article
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
- Functional significance of 8-isoprostanes in sinonasal disease and asthma.Respiratory medicineArticle
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveThe reduction of forced expiratory volume in 1 s (FEV
methodsWe used the methacholine challenge data from participants in five studies of the ALA-ACRC to determine the closing index, defined as the contribution of airway closure to the decrease in FEV
resultsThere were a total of 936 participants with asthma, among whom the median closing index was 0.67 relative to that of a published healthy population of 0.54. A higher closing index was associated with increased age (10-year increments) (0.04, 95% CI = 0.02, 0.05, P < 0.005) and obesity (0.07, 95% CI = 0.03, 0.10, P < 0.001). There was no association between the closing index and asthma control.
conclusionOur findings confirm that airway closure in response to methacholine occurs in a large, diverse population of asthmatic participants, and that increased airway closure is associated with older age and obesity. These findings suggest that therapies targeting airway closure may be important in patients with a high closing index.
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