Evidence map›Paper›PMID 30838706›Full record

Trial reportPhytotherapy research : PTR2019

A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.

Muhammed Majeed, Shaheen Majeed, Narayanan K Narayanan, Kalyanam Nagabhushanam

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Phytotherapy research : PTR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04091555 (Evaluation of the Impact of the HL Natural, Inc. Tension Relief Product on the Reduction of Symptoms in Adults Who Suffer From Mild to Moderate Tension Headaches), which is not on this map. Cited by 59 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 6 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04091555 nacompletednot on this map

Evaluation of the Impact of the HL Natural, Inc. Tension Relief Product on the Reduction of Symptoms in Adults Who Suffer From Mild to Moderate Tension Headaches

TypeinterventionalSponsorHawthorne Effect Inc.Ran2019 to 2020Enrolled117ConditionsTension, HeadacheArmsHLNatural Tension
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  7. Trial
  8. Efficacy ofNutrients · 2023
    Trial
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  11. Trial
  12. Article
  13. International journal of molecular sciences · 2026
    Article
  14. Review
  15. Efficacy and Safety ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Muhammed MajeedSami Labs Limited, Research & Development Division, Bangalore, India.
Shaheen MajeedSabinsa Corporation, Research & Development Division, Payson, Utah.
Narayanan K NarayananSabinsa Corporation, Research & Development Division, East Windsor, New Jersey.
Kalyanam NagabhushanamSabinsa Corporation, Research & Development Division, East Windsor, New Jersey.ORCID https://orcid.org/0000-0001-9470-4110
Windsor Dermatology · USSabin Vaccine Institute · USSami Labs (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A double-blind, placebo-controlled human trial was conducted to evaluate the safety and efficacy of a standardized oral supplementation of Boswellin®, a novel extract of Boswellia serrata extract (BSE) containing 3-acetyl-11-keto-β-boswellic acid (AKBBA) with β-boswellic acid (BBA). A total of 48 patients with osteoarthritis (OA) of the knee were randomized and allocated to the BSE and placebo groups for intervention. Patients were administered BSE or placebo for a period of 120 days. The trial results revealed that BSE treatment significantly improved the physical function of the patients by reducing pain and stiffness compared with placebo. Radiographic assessments showed improved knee joint gap and reduced osteophytes (spur) confirming the efficacy of BSE treatment. BSE also significantly reduced the serum levels of high-sensitive C-reactive protein, a potential inflammatory marker associated with OA of the knee. No serious adverse events were reported. This is the first study with BSE conducted for a period of 120 days, longer than any other previous clinical trial on patients with OA of the knee. The findings provide evidence that biologically active constituents of BSE, namely, AKBBA and BBA, act synergistically to exert anti-inflammatory/anti-arthritic activity showing improvement in physical and functional ability and reducing the pain and stiffness.

Indexed as

AgedBoswelliaDouble-Blind MethodFemaleHumansMaleMiddle AgedOsteoarthritis, KneePainPain MeasurementPilot ProjectsPlant ExtractsTriterpenesacetyl-11-ketoboswellic acidboswellic acidPlant ExtractsTriterpenesanti-inflammatoryBoswellia serrata extractcathepsin Ghigh-sensitive C-reactive proteinknee osteoarthritismicrosomal prostaglandin E synthase-1

Identifiers

PMID30838706
PMCPMC6681146
OpenAlexW2922366263

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.