ArticleVox sanguinis2019
Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa.
Article in Vox sanguinis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cardiac output measurement in Malawian children ages 2 months-12 years hospitalised with severe anaemia (COM-TRACT).International health · 2026Trial
- Whole blood versus red cell concentrates for children with severe anaemia: a secondary analysis of the Transfusion and Treatment of African Children (TRACT) trial.The Lancet. Global health · 2022Trial
- Transfusion management of severe anaemia in African children: a consensus algorithm.British journal of haematology · 2021Trial
- Immediate Transfusion in African Children with Uncomplicated Severe Anemia.The New England journal of medicine · 2019Trial
- Transfusion Volume for Children with Severe Anemia in Africa.The New England journal of medicine · 2019Trial
- Red blood cell alloantibodies in paediatric transfusion in sub-Saharan Africa: A new cohort and literature review.EJHaem · 2023Article
- A predictive algorithm for identifying children with sickle cell anemia among children admitted to hospital with severe anemia in Africa.American journal of hematology · 2022Article
- Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test.British journal of haematology · 2021Review
- Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa.Vox sanguinis · 2020Article
- Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial.The Lancet. Global health · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors.
Funding
Abstract
BACKGROUND AND
objectivesPaediatric blood transfusion for severe anaemia in hospitals in sub-Saharan Africa remains common. Yet, reports describing the haematological quality of donor blood or storage duration in routine practice are very limited. Both factors are likely to affect transfusion outcomes. MATERIALS AND
methodsWe undertook three audits examining the distribution of pack types, haematological quality and storage duration of donor blood used in a paediatric clinical trial of blood at four hospitals in Africa (Uganda and Malawi).
resultsThe overall distribution of whole blood, packed cells (plasma-reduced by centrifugation) and red cell concentrates (RCC) (plasma-reduced by gravity-dependent sedimentation) used in a randomised trial was 40·7% (N = 1215), 22·4% (N = 669) and 36·8% (N = 1099), respectively. The first audit found similar median haematocrits of 57·0% (50·0,74·0), 64·0% (52·0,72·5; P = 0·238 vs. whole blood) and 56·0% (48·0,67·0; P = 0·462) in whole blood, RCC and packed cells, respectively, which resulted from unclear pack labelling by blood transfusion services (BTS). Re-training of the BTS, hospital blood banks and clinical teams led to, in subsequent audits, significant differences in median haematocrit and haemoglobins across the three pack types and values within expected ranges. Median storage duration time was 12 days (IQR: 6, 19) with 18·2% (537/2964) over 21 days in storage. Initially, 9 (2·8%) packs were issued past the recommended duration of storage, dropping to 0·3% (N = 7) in the third audit post-training.
conclusionThe study highlights the importance of close interactions and education between BTS and clinical services and the importance of haemovigilance to ensure safe transfusion practice.
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