Evidence map›Paper›PMID 30838645›Full record

ArticleThe British journal of dermatology2019

Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults.

J I Silverberg, J M Gelfand, D J Margolis, M Boguniewicz, L Fonacier, M H Grayson, P Y Ong, Z C Chiesa Fuxench, E L Simpson

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of dermatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07009483 (Effectiveness of Psychodermatologic Educational Modules on Atopic Dermatitis Patient Outcomes), which is not on this map. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07009483 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effectiveness of Psychodermatologic Educational Modules on Atopic Dermatitis Patient Outcomes

TypeinterventionalSponsorUniversity of AlbertaRan2025 to 2026Enrolled42ConditionsAtopic Dermatitis (AD)ArmsPatient education modules providing information on the psychological aspects of atopic dermatitis treatment and management.
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Addiction and chronic skin diseases: The missing role of itch.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Prevalence of Mental Health Symptoms in Patients With Atopic Dermatitis: A Systematic Review and Meta-Analysis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

J I SilverbergFeinberg School of Medicine, Northwestern University, Chicago, IL, U.S.A.ORCID 0000-0003-3686-7805
J M GelfandSchool of Medicine, University of Pennsylvania Perelman, Philadelphia, PA, U.S.A.
D J MargolisSchool of Medicine, University of Pennsylvania Perelman, Philadelphia, PA, U.S.A.
M BoguniewiczNational Jewish Health, Denver, CO, U.S.A.
L FonacierNYU Winthrop Hospital, Mineola, NY, U.S.A.
M H GraysonNationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, U.S.A.
P Y OngChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, U.S.A.
Z C Chiesa FuxenchSchool of Medicine, University of Pennsylvania Perelman, Philadelphia, PA, U.S.A.
E L SimpsonOregon Health & Science University, Portland, OR, U.S.A.

Funding

Asthma and Allergy Foundation of America in partnership with the National Eczema AssociationSanofi Genzyme and Regeneron
6 · The paper itself

Abstract

backgroundThe relationship between atopic dermatitis (AD), anxiety and depression in the U.S. adult population is not well established.

objectivesTo determine the relationship of AD and its severity with symptoms and diagnosis of anxiety and depression in U.S. adults.

methodsA cross-sectional, population-based study of 2893 adults was performed. AD was determined using modified U.K. Diagnostic Criteria.

resultsAdults with AD vs. those without AD had higher mean Hospital Anxiety and Depression Scale anxiety (HADS-A) (7·7 vs. 5·6) and depression (HADS-D) (6·0 vs. 4·3) scores and higher prevalences of abnormal (≥ 11) HADS-A (28·6% vs. 15·5%) and HADS-D (13·5% vs. 9·0%) scores. In multivariable linear and logistic regression models controlling for sociodemographics, AD was associated with significantly higher mean HADS-A and HADS-D scores (7·7 and 6·0) and higher odds of abnormal HADS-A [odds ratio (OR) 2·19, 95% confidence interval (CI) 1·65-2·91] and HADS-D scores (OR 1·50, 95% CI 1·04-2·17) (P ≤ 0·03 for all). Mean and abnormal HADS-A and HADS-D scores were increased in moderate and severe/very severe self-reported global AD severity, Patient-Oriented Eczema Measure (POEM), Patient-Oriented Scoring AD (PO-SCORAD), PO-SCORAD itch and sleep (P < 0·0001 for all). All respondents with severe PO-SCORAD, POEM and PO-SCORAD itch had borderline or abnormal HADS-A and HADS-D scores. Adults with AD vs. those without AD had higher prevalence of self-reported healthcare-diagnosed anxiety or depression in the past year (40·0% vs. 17·5%). Many adults with AD who had borderline and/or abnormal HADS-A or HADS-D scores reported no diagnosis of anxiety or depression.

conclusionsAD is associated with significantly increased anxiety and depression, which may go undiagnosed. What's already known about this topic? Previous studies found higher rates of anxiety and depression in clinical cohorts of patients with atopic dermatitis. What does this study add? This study found dramatically higher rates of anxiety and depression among adults with atopic dermatitis in the U.S. population, which was primarily driven by atopic dermatitis severity. Anxiety and depression often go undiagnosed in adults with atopic dermatitis.

Indexed as

Quality of LifeAdolescentAdultAgedAged, 80 and overAnxietyCross-Sectional StudiesDepressionDermatitis, AtopicFemaleHumansMaleMiddle AgedPrevalencePsychiatric Status Rating ScalesSelf Report

Identifiers

PMID30838645
PMCPMC6850653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.