Evidence map›Paper›PMID 30838518›Full record

ArticleMolecular neurobiology2019

Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture.

Hércules Rezende Freitas, Alinny Rosendo Isaac, Thayane Martins Silva, Geyzzara Oliveira Ferreira Diniz, Yara Dos Santos Dabdab, Eduardo Cosendey Bockmann, Marília Zaluar Passos Guimarães, Karin da Costa Calaza, Fernando Garcia de Mello, Ana Lucia Marques Ventura and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. The Healthy and Diseased Retina Seen through Neuron-Glia Interactions.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hércules Rezende FreitasLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Alinny Rosendo IsaacLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Thayane Martins SilvaLaboratory of Neurochemistry, Institute of Biology, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Geyzzara Oliveira Ferreira DinizBiomedical Institute, Universidade Federal do Estado do Rio de Janeiro, Rua Frei Caneca, 94, Rio de Janeiro, RJ, 20211-040, Brazil.
Yara Dos Santos DabdabBiomedical Institute, Universidade Federal do Estado do Rio de Janeiro, Rua Frei Caneca, 94, Rio de Janeiro, RJ, 20211-040, Brazil.
Eduardo Cosendey BockmannLaboratory of Retina Neurobiology, Institute of Biology, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Marília Zaluar Passos GuimarãesLaboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Karin da Costa CalazaLaboratory of Retina Neurobiology, Institute of Biology, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Fernando Garcia de MelloLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Ana Lucia Marques VenturaLaboratory of Neurochemistry, Institute of Biology, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Ricardo Augusto de Melo ReisLaboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Guilherme Rapozeiro FrançaBiomedical Institute, Universidade Federal do Estado do Rio de Janeiro, Rua Frei Caneca, 94, Rio de Janeiro, RJ, 20211-040, Brazil. guilherme.franca@unirio.br.
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BRUniversidade Federal do Estado do Rio de Janeiro · BR

Funding

Clinical Science Research & Development 1Conselho Nacional de Desenvolvimento Científico e Tecnológico 2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 4Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional 3
6 · The paper itself

Abstract

Development of progenitors in the embryonic retina is modulated by signaling molecules, and cannabinoid receptors are highly expressed in the early developing retina. Here, we investigated whether the CB1/CB2 receptor agonist WIN 5212-2 (WIN) modulated the proliferation, viability, and calcium responses in chick embryo retinal progenitors in culture. A decline in [

Indexed as

AnimalsApoptosisBenzoxazinesCalciumCannabinoidsCell ProliferationCells, CulturedCell SurvivalChick EmbryoFluorescent DyesMorpholinesNaphthalenesNestinNeurogliaPhenotypeReceptor, Cannabinoid, CB1(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanoneBenzoxazinesCalciumCannabinoidsFluorescent DyesMorpholinesNaphthalenesNestinReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, Purinergic P2X7ATPCalcium signalingEndocannabinoidMüller gliaP2X7 receptorRetina

Identifiers

PMID30838518
OpenAlexW2922027445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.