Evidence map›Paper›PMID 30838489›Full record

ArticleJournal of neuro-oncology2019

SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation.

Fei Liu, Christopher D Cox, Reshmi Chowdhury, Laura Dovek, Huytram Nguyen, Tie Li, Sichen Li, Byram Ozer, Arthur Chou, Nhung Nguyen and 10 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. AJournal of gastrointestinal oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Fei LiuDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Christopher D CoxDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Reshmi ChowdhuryDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Laura DovekDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Huytram NguyenDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Tie LiDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Sichen LiDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Byram OzerDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Arthur ChouDepartment of Neurosurgery, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Nhung NguyenDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Bowen WeiPathology and Laboratory Medicine, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Joseph AntoniosDepartment of Neurosurgery, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Horacio SotoDepartment of Neurosurgery, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Harley KornblumDepartment of Psychiatry and Biobehavioral Sciences, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Linda LiauDepartment of Neurosurgery, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Robert PrinsDepartment of Neurosurgery, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
P Leia NghiemphuDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
William YongPathology and Laboratory Medicine, David Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Timothy CloughesyDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA.
Albert LaiDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, 710 Westwood Plaza, Suite 1-230 RNRC, Los Angeles, CA, 90095, USA. albertlai@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-7265-2986
University of California, Los Angeles · US

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David A. Nathanson · 2017 to 2026
$25.2M
Investigation of tumor suppressive miR-148a in IDH mutant gliomasR01CA179071 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAI, ALBERT · 2014 to 2018
$1.6M
National Institutes of Health R01CA179071NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA179071Wellcome Trust
6 · The paper itself

Abstract

purposeBoth IDH1-mutated and wild-type gliomas abundantly display aberrant CpG island hypermethylation. However, the potential role of hypermethylation in promoting gliomas, especially the most aggressive form, glioblastoma (GBM), remains poorly understood.

methodsWe analyzed RRBS-generated methylation profiles for 11 IDH1

resultsWe identified SPINT2 as a candidate tumor-suppressor gene within a group of CpG islands (designated G

conclusionsWe defined a previously under-recognized group of coordinately methylated CpG islands common to both IDH1

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticMutationAnimalsApoptosisCell ProliferationCpG IslandsGlioblastomaHumansIsocitrate DehydrogenaseMembrane GlycoproteinsMiceMice, Inbred NODMice, SCIDPromoter Regions, GeneticProto-Oncogene Proteins c-metIDH1 protein, humanIsocitrate DehydrogenaseMembrane GlycoproteinsMET protein, humanProto-Oncogene Proteins c-metSPINT2 protein, humanCpG island methylationGlioblastomaHGF/c-MetSPINT2Tumor suppressor

Identifiers

PMID30838489
PMCPMC6516751
OpenAlexW2918236561

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.