Evidence map›Paper›PMID 30838443›Full record

Trial reportSurgery today2019

Preoperative FOLFOX in resectable locally advanced rectal cancer can be a safe and promising strategy: the R-NAC-01 study.

Nobuki Ichikawa, Shigenori Homma, Tohru Funakoshi, Masahiro Hattori, Masanori Sato, You Kamiizumi, Kazuyoshi Omori, Masaru Nomura, Ryoichi Yokota, Masahiko Koike and 14 more

Abstract readClinical Trial, Phase IIMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Surgery today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nobuki IchikawaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.ORCID http://orcid.org/0000-0002-8934-9684
Shigenori HommaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan. homma.s@nifty.com.
Tohru FunakoshiDepartment of Surgery, Asahikawa-Kosei General Hospital, Asahikawa, 078-8211, Japan.
Masahiro HattoriDepartment of Surgery, Sapporo Hokuyu Hospital, Sapporo, 003-0006, Japan.
Masanori SatoDepartment of Surgery, Sapporo Hokuyu Hospital, Sapporo, 003-0006, Japan.
You KamiizumiDepartment of Surgery, Iwamizawa Municipal Hospital, Iwamizawa, 068-8555, Japan.
Kazuyoshi OmoriDepartment of Surgery, Keiwakai Ebetsu Hospital, Ebetsu, 069-0817, Japan.
Masaru NomuraDepartment of Surgery, Keiwakai Ebetsu Hospital, Ebetsu, 069-0817, Japan.
Ryoichi YokotaDepartment of Surgery, Sunagawa City Medical Center, Sunagawa, 073-0196, Japan.
Masahiko KoikeDepartment of Surgery, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, 062-0931, Japan.
Hirofumi KonDepartment of Surgery, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, 062-0931, Japan.
Keisa TakedaDepartment of Surgery, KKR Sapporo Medical Center, Toyohira-ku, Sapporo, 062-0931, Japan.
Hiroyuki IshizuDepartment of Surgery, Sapporo-Kosei, General Hospital, Sapporo, 060-0033, Japan.
Kunihiro HiroseDepartment of Surgery, Tomakomai City Hospital, Tomakomai, 053-8567, Japan.
Daisuke KurayaDepartment of Surgery, Tomakomai City Hospital, Tomakomai, 053-8567, Japan.
Takahisa IshikawaDepartment of Surgery, Abashiri-Kosei General Hospital, Abashiri, 093-0076, Japan.
Ryohei MurataDepartment of Surgery, Otaru General Hospital, Otaru, 047-8550, Japan.
Hiroaki IijimaClinical Research and Medical Innovation Center, Hokkaido University Hospital, Sapporo, 060-8638, Japan.
Futoshi KawamataDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Tadashi YoshidaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Yosuke OhnoDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Nozomi MinagawaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Norihiko TakahashiDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Akinobu TaketomiDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to assess the safety of rectal surgery after 5-fluorouracil-leucovorin-oxaliplatin chemotherapy (FOLFOX6).

methodsThis was a prospective, multicenter study in 11 Japanese hospitals. We included patients with rectal cancer who received 4 courses of modified FOLFOX6 (mFOLFOX6) before rectal surgery and examined the postoperative complication rate, the clinicopathological response, and the rate of chemotherapy-related adverse events (UMIN 000012559).

resultsThe study population included 36 men and 5 women. The average age of the patients was 60.8 years and the average body mass index was 23.1 kg/m

conclusionsSurgery after four courses of mFOLFOX6 chemotherapy can be a safe and promising strategy for patients with locally advanced rectal cancer.

Indexed as

Neoadjuvant TherapyAdenocarcinomaAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyDigestive System Surgical ProceduresFemaleFluorouracilHumansLeucovorinMaleMiddle AgedOrganoplatinum CompoundsPreoperative CareProspective StudiesFluorouracilLeucovorinOrganoplatinum CompoundsDownstagingFOLFOXNeoadjuvant therapyRectal cancerResection

Identifiers

PMID30838443

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.