Evidence map›Paper›PMID 30838442›Full record

ArticleSurgery today2019

Predictive value of the Ki67 index for lymph node metastasis of small non-functioning pancreatic neuroendocrine neoplasms.

Toshihiko Masui, Asahi Sato, Kenzo Nakano, Yuichiro Uchida, Akitada Yogo, Takayuki Anazawa, Kazuyuki Nagai, Yoshiya Kawaguchi, Kyoichi Takaori, Shinji Uemoto

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In one paragraph

Article in Surgery today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Toshihiko MasuiDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan. tmasui@kuhp.kyoto-u.ac.jp.
Asahi SatoDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Kenzo NakanoDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Yuichiro UchidaDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Akitada YogoDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Takayuki AnazawaDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Kazuyuki NagaiDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Yoshiya KawaguchiDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Kyoichi TakaoriDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Shinji UemotoDepartment of Surgery, Kyoto University, 54 Shogoin, Kawaracho, Sakyo, Kyoto, 606-8507, Japan.
Kyoto University · JP

Funding

Japan Society for the Promotion of Science JP18K08677
6 · The paper itself

Abstract

backgroundWe evaluated the clinicopathological factors associated with lymph node metastasis in patients with non-functioning pancreatic neuroendocrine neoplasms (PanNENs), focusing on the risk factors and range of lymph node metastasis for tumors ≤ 2 cm in diameter.

methodsThe subjects of this study were patients with PanNENs consecutively diagnosed at our hospital between January, 2000 and June, 2018. We analyzed 69 patients who underwent R0 resection of a non-functioning sporadic PanNEN with no distant metastasis, as well as 43 patients with tumors ≤ 20 mm in radiological diameter.

resultsNineteen patients (27.5%), including 7 (16.3%) with a small PanNEN, had lymph node metastasis. A large radiological diameter, a high Ki67 index, and cyst formation correlated significantly with positive lymph node metastasis. In patients with tumors ≤ 20 mm in diameter, a high Ki67 index correlated significantly with lymph node metastasis. When we set the cut-off Ki67 index as 3.3%, 2 of 43 patients had lymph node metastasis. Tumors in the uncinate process readily metastasized to the region around the superior mesenteric artery.

conclusionsThese findings suggest that a high Ki67 index indicates a risk of lymph node metastasis for tumors ≤ 20 mm in diameter and that lymphadenectomy should be performed in the region spatially adjacent to the primary tumor.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorFemaleHumansKi-67 AntigenLymphatic MetastasisLymph Node ExcisionMaleMesenteric Artery, SuperiorMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsPredictive Value of TestsTomography, X-Ray ComputedBiomarkers, TumorKi-67 AntigenDissectionKi67Lymph node metastasisNon-functioningSmall PanNEN

Identifiers

PMID30838442
OpenAlexW2920091779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.