Evidence map›Paper›PMID 30838324›Full record

ArticleeNeuro

Developmental Axon Degeneration Requires TRPV1-Dependent Ca

Aaron D Johnstone, Andrés de Léon, Nicolás Unsain, Julien Gibon, Philip A Barker

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Axonal spheroids in neurodegeneration.Molecular and cellular neurosciences · 2021
    Review
  4. TRP Channels Regulation of Rho GTPases in Brain Context and Diseases.Frontiers in cell and developmental biology · 2020
    Review
  5. p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Aaron D JohnstoneDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Andrés de LéonDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Nicolás UnsainInstituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Córdoba, Córdoba 5016, Argentina.
Julien GibonDepartment of Biology, University of British Columbia Okanagan, Kelowna, British Columbia V1V 1V7, Canada.ORCID 0000-0001-7216-5806
Philip A BarkerDepartment of Biology, University of British Columbia Okanagan, Kelowna, British Columbia V1V 1V7, Canada.
Montreal Neurological Institute and Hospital · CAUniversity of British Columbia · CAUniversidad Nacional de Córdoba · AR

Funding

CIHR MOP137057
6 · The paper itself

Abstract

Development of the nervous system relies on a balance between axon and dendrite growth and subsequent pruning and degeneration. The developmental degeneration of dorsal root ganglion (DRG) sensory axons has been well studied in part because it can be readily modeled by removing the trophic support by nerve growth factor (NGF)

Indexed as

AnimalsAxonsCalciumCations, DivalentCells, CulturedGanglia, SpinalMice, Inbred C57BLMice, TransgenicNADPH OxidasesNerve DegenerationNerve Growth FactorProtein Kinase CReactive Oxygen SpeciesTRPV Cation ChannelsCalciumCations, DivalentNADPH OxidasesNerve Growth FactorProtein Kinase CReactive Oxygen SpeciesTRPV1 receptorTRPV Cation ChannelscalciumneurodegenerationNGFpruningTrkATRPV1

Identifiers

PMID30838324
PMCPMC6399429
OpenAlexW2912076336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.