Evidence map›Paper›PMID 30838307›Full record

ReviewMovement disorders clinical practice2019

Levodopa-Induced Neuropathy: A Systematic Review.

Alberto Romagnolo, Aristide Merola, Carlo Alberto Artusi, Mario Giorgio Rizzone, Maurizio Zibetti, Leonardo Lopiano

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Movement disorders clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07430722 (A Cross-sectional Study of Serum Vitamin B6 Levels in People Living With Parkinson's Disease), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07430722 completednot on this mapstarted 2024, after this paper: background citation

A Cross-sectional Study of Serum Vitamin B6 Levels in People Living With Parkinson's Disease

TypeobservationalSponsorUniversity of RochesterRan2024 to 2026Enrolled288ConditionsParkinson's Disease (PD)
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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  17. Parkinson's disease and vitamins: a focus on vitamin B12.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alberto RomagnoloDepartment of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.ORCID https://orcid.org/0000-0002-1312-1843
Aristide MerolaGardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati Cincinnati Ohio USA.ORCID https://orcid.org/0000-0002-5587-726X
Carlo Alberto ArtusiDepartment of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.ORCID https://orcid.org/0000-0001-8579-3772
Mario Giorgio RizzoneDepartment of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.
Maurizio ZibettiDepartment of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.
Leonardo LopianoDepartment of Neuroscience "Rita Levi Montalcini" University of Turin Torino Italy.
University of Turin · ITUniversity of Cincinnati · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical, neurophysiological, and pathological evidence suggest an association between Parkinson's disease (PD) and peripheral neuropathy (PNP), with a possible causative role of levodopa metabolic products, such as homocysteine and methylmalonic acid.

methodsWe conducted a systematic review of studies reporting cases of PNP in l-dopa-treated PD patients indexed in PubMed between January 1990 and March 2018.

resultsWe identified 38 articles reporting cases of PNP in PD patients treated with oral l-dopa or with l-dopa/carbidopa intestinal gel infusion (LCIG). Prevalence of PNP was 30.2% in the former group and 42.1% in the latter. Oral l-dopa was mostly associated with slowly progressive PNP, whereas LCIG showed an acute or subacute onset in 35.7% of cases. In both groups, there was an association between PNP and higher l-dopa doses, as well as with the following biochemical alterations: increased homocysteine; reduced vitamin B12; increased methylmalonic acid; and reduced vitamin B6. A skin biopsy was performed in 181 patients, showing signs of small fibers neuropathy in 169 (93.4%). Positive, yet preliminary, results were observed in patients receiving periodic vitamin supplementation.

conclusionsOver one third of PD patients in treatment with l-dopa may develop PNP, with a significantly higher prevalence of acute and subacute forms in those receiving LCIG. Pathogenic mechanisms remain unclear, but possibly related to a complex interplay between peripheral neurodegenerative processes and l-dopa neurotoxic metabolites. Prospective, randomized, clinical trials are required to identify factors associated with the onset and progression of PD-associated PNP and clarify the protective role of B-group vitamin supplementation.

Indexed as

LCIGlevodopaneuropathyParkinson's diseasesmall fibers

Identifiers

PMID30838307
PMCPMC6384168
OpenAlexW2894011917

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.