Evidence map›Paper›PMID 30838179›Full record

ArticleFrontiers in cellular and infection microbiology2019

Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses.

Beng San Yeoh, Andrew T Gewirtz, Matam Vijay-Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Repression of theJournal of veterinary research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Beng San YeohGraduate Program in Immunology and Infectious Disease, Pennsylvania State University, University Park, PA, United States.
Andrew T GewirtzCenter for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Matam Vijay-KumarDepartment of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States.
Georgia State University · USPennsylvania State University · USUniversity of Toledo Medical Center · US

Funding

Pathophysiology of TLR5KO ColitisR01DK083890 · NIDDK · GEORGIA STATE UNIVERSITY · PI GEWIRTZ, ANDREW T · 2010 to 2023
$5.0M
Flagellin-Induced Gut Epithelial Chemokine SecretionR01DK061417 · NIDDK · GEORGIA STATE UNIVERSITY · PI GEWIRTZ, ANDREW T · 2003 to 2012
$3.4M
Role of Lipocalin 2 Inflammatory Bowel DiseaseR01DK097865 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI VIJAY-KUMAR, MATAM · 2013 to 2015
$897k
NIDDK NIH HHS R01 DK061417NIDDK NIH HHS R01 DK083890NIDDK NIH HHS R01 DK097865
6 · The paper itself

Abstract

The host immune system is constantly exposed to diverse microbial ligands, including flagellin (FliC; a ligand for TLR5 and NLRC4) and lipopolysaccharide (LPS; a ligand for TLR4), which could induce immune tolerance to subsequent exposure. Herein, we investigated the extent to which FliC induces self-tolerance

Indexed as

Adaptive ImmunityImmune ToleranceImmunity, InnateAnimalsApoptosis Regulatory ProteinsCalcium-Binding ProteinsFlagellinMiceMice, KnockoutSalmonella typhimuriumToll-Like Receptor 5Apoptosis Regulatory ProteinsCalcium-Binding ProteinsFlagellinIpaf protein, mouseTlr5 protein, mouseToll-Like Receptor 5antibodiesimmune toleranceinfectioninnate immunityLPSsalmonella

Identifiers

PMID30838179
PMCPMC6390806
OpenAlexW2916437988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.