Evidence map›Paper›PMID 30838177›Full record

ArticleFrontiers in cellular and infection microbiology2019

Novel Synthetic Polyamines Have Potent Antimalarial Activities

Kamal El Bissati, Henry Redel, Li-Min Ting, Joseph D Lykins, Martin J McPhillie, Rajendra Upadhya, Patrick M Woster, Nigel Yarlett, Kami Kim, Louis M Weiss

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Article
  6. Microorganisms · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Kamal El BissatiDepartment of Ophthalmology and Visual Science, The University of Chicago, Chicago, IL, United States.
Henry RedelDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Li-Min TingDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Joseph D LykinsDepartment of Internal Medicine and Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA, United States.
Martin J McPhillieSchool of Chemistry, University of Leeds, Leeds, United Kingdom.
Rajendra UpadhyaDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Patrick M WosterDepartment of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, United States.
Nigel YarlettHaskins Laboratories, Department of Chemistry and Physical Sciences, Pace University, New York, NY, United States.
Kami KimDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Louis M WeissDepartment of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States.
Albert Einstein College of Medicine · USMontefiore Medical Center · USMedical University of South Carolina · USPace University · USUniversity Health System · USUniversity of Chicago · USUniversity of Leeds · GB

Funding

A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondiiRC4AI092801 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KIM, KAMI, SULLIVAN, WILLIAM J · 2010 to 2010
$5.6M
New Opportunistic Infections in AIDS MicrosporidosisR01AI031788 · NIAID · YESHIVA UNIVERSITY · PI WEISS, LOUIS M. · 1992 to 2011
$4.6M
Toxoplasma Epigenomics and Gene ExpressionR01AI087625 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KIM, KAMI · 2010 to 2014
$3.5M
Identification of LSD1 inhibitors targeting epigenetic regulation in tumor cellsR01CA149095 · NCI · WAYNE STATE UNIVERSITY · PI WOSTER, PATRICK M · 2010 to 2014
$1.3M
NCI NIH HHS R01 CA149095NIAID NIH HHS R01 AI031788NIAID NIH HHS R01 AI087625NIAID NIH HHS RC4 AI092801
6 · The paper itself

Abstract

Twenty-two compounds belonging to several classes of polyamine analogs have been examined for their ability to inhibit the growth of the human malaria parasite

Indexed as

AnimalsAntimalarialsDisease Models, AnimalDrug SynergismInhibitory Concentration 50MalariaMiceParasite LoadParasitemiaParasitic Sensitivity TestsPlasmodium falciparumPlasmodium yoeliiPolyaminesSpermidineSpermineAntimalarialsPolyaminesSpermidineSperminemalariaPlasmodiumpolyaminespermidinespermidine synthasesperminethiourea

Identifiers

PMID30838177
PMCPMC6382690
OpenAlexW2915051746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.