Evidence map›Paper›PMID 30838161›Full record

ReviewImmune network2019

The Role of Plasmacytoid Dendritic Cells in Gut Health.

Hye-Yeon Won, Ju-Young Lee, Dahye Ryu, Hyung-Taek Kim, Sun-Young Chang

Open access · bronzeAbstract readReview
In one paragraph

Review in Immune network, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Dendritic cells in food allergy, treatment, and tolerance.The Journal of allergy and clinical immunology · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Gut Innate Immunity and HIV Pathogenesis.Current HIV/AIDS reports · 2021
    Review
  9. Review
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hye-Yeon WonResearch Institute of Pharmaceutical Science and Technology (RIPST), Ajou University College of Pharmacy, Suwon, 16499, Korea.ORCID https://orcid.org/0000-0002-3290-2733
Ju-Young LeeResearch Institute of Pharmaceutical Science and Technology (RIPST), Ajou University College of Pharmacy, Suwon, 16499, Korea.
Dahye RyuResearch Institute of Pharmaceutical Science and Technology (RIPST), Ajou University College of Pharmacy, Suwon, 16499, Korea.
Hyung-Taek KimResearch Institute of Pharmaceutical Science and Technology (RIPST), Ajou University College of Pharmacy, Suwon, 16499, Korea.ORCID https://orcid.org/0000-0003-4430-2492
Sun-Young ChangResearch Institute of Pharmaceutical Science and Technology (RIPST), Ajou University College of Pharmacy, Suwon, 16499, Korea.ORCID https://orcid.org/0000-0001-7336-9245
Ajou University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) are a unique subset of cells with different functional characteristics compared to classical dendritic cells. The pDCs are critical for the production of type I IFN in response to microbial and self-nucleic acids. They have an important role for host defense against viral pathogen infections. In addition, pDCs have been well studied as a critical player for breaking tolerance to self-nucleic acids that induce autoimmune disorders such as systemic lupus erythematosus. However, pDCs have an immunoregulatory role in inducing the immune tolerance by generating Tregs and various regulatory mechanisms in mucosal tissues. Here, we summarize the recent studies of pDCs that focused on the functional characteristics of gut pDCs, including interactions with other immune cells in the gut. Furthermore, the dynamic role of gut pDCs will be investigated with respect to disease status including gut infection, inflammatory bowel disease, and cancers.

Indexed as

GutHost defenseImmune tolerancePlasmacytoid dendritic cellType I interferon

Identifiers

PMID30838161
PMCPMC6399095
OpenAlexW2919535784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.