Evidence map›Paper›PMID 30837995›Full record

ArticleFrontiers in immunology2019

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species.

Jamie E Fegan, Charles Calmettes, Epshita A Islam, Sang Kyun Ahn, Somshukla Chaudhuri, Rong-Hua Yu, Scott D Gray-Owen, Trevor F Moraes, Anthony B Schryvers

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  9. PreclinicalFrontiers in immunology · 2025
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  13. Immunodominant extracellular loops ofbioRxiv : the preprint server for biology · 2024
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  17. Review
  18. Article
  19. Frontiers in veterinary science · 2023
    Review
  20. Immune responses toFrontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jamie E FeganDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Charles CalmettesDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
Epshita A IslamDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
Sang Kyun AhnDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Somshukla ChaudhuriDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Rong-Hua YuDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Scott D Gray-OwenDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Trevor F MoraesDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada.
Anthony B SchryversDepartment of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
University of Toronto · CAUniversity of Calgary · CA

Funding

Using gonococcal TonB-dependent transporters as vaccine antigensU19AI144182 · NIAID · GEORGIA STATE UNIVERSITY · PI CORNELISSEN, CYNTHIA N · 2019 to 2023
$9.3M
Production of a Gonococcal Vaccine for Countering Antimicrobial ResistanceR01AI141229 · NIAID · UNIVERSITY OF CALGARY · PI GRAY-OWEN, SCOTT D, MORAES, TREVOR F · 2019 to 2024
$4.4M
Rational design of transferrin binding protein-based vaccines to combat gonorrheaR01AI125421 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CORNELISSEN, CYNTHIA N, GRAY-OWEN, SCOTT D · 2017 to 2021
$3.1M
NIAID NIH HHS R01 AI125421NIAID NIH HHS R01 AI141229NIAID NIH HHS U19 AI144182
6 · The paper itself

Abstract

The surface transferrin receptor proteins from

Indexed as

Amino Acid SequenceAnimalsBacterial Outer Membrane ProteinsBinding SitesFemaleGonorrheaIronMaleMiceMice, Inbred C57BLNeisseria gonorrhoeaeNeisseria meningitidisProtein BindingRabbitsSequence AlignmentSwineBacterial Outer Membrane ProteinsIronTransferrinTransferrin-Binding Protein ATransferrin-Binding Protein Bepitopehybrid antigenlipoproteinouter membrane proteinprotein engineeringscaffold

Identifiers

PMID30837995
PMCPMC6389628
OpenAlexW2917355774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.