Evidence map›Paper›PMID 30837941›Full record

ReviewFrontiers in neurology2019

Inflammation, Infectious Triggers, and Parkinson's Disease.

Elisa Caggiu, Giannina Arru, Sepideh Hosseini, Magdalena Niegowska, GianPietro Sechi, Ignazio Roberto Zarbo, Leonardo A Sechi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.

  1. Pooled it
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  7. Montelukast alleviates neuroinflammation and improves motor functions in the line 61 model of Parkinson's disease: An exploratory study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elisa CaggiuMicrobiology Section, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Giannina ArruMicrobiology Section, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Sepideh HosseiniMicrobiology Section, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Magdalena NiegowskaMicrobiology Section, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
GianPietro SechiDepartment of Clinical, Surgical and Experimental Medicine, Neurological Clinic, University of Sassari, Sassari, Italy.
Ignazio Roberto ZarboDepartment of Clinical, Surgical and Experimental Medicine, Neurological Clinic, University of Sassari, Sassari, Italy.
Leonardo A SechiMicrobiology Section, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
University of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons of the substantia nigra pars compacta with a reduction of dopamine concentration in the striatum. The complex interaction between genetic and environmental factors seems to play a role in determining susceptibility to PD and may explain the heterogeneity observed in clinical presentations. The exact etiology is not yet clear, but different possible causes have been identified. Inflammation has been increasingly studied as part of the pathophysiology of neurodegenerative diseases, corroborating the hypothesis that the immune system may be the nexus between environmental and genetic factors, and the abnormal immune function can lead to disease. In this review we report the different aspects of inflammation and immune system in Parkinson's disease, with particular interest in the possible role played by immune dysfunctions in PD, with focus on autoimmunity and processes involving infectious agents as a trigger and alpha-synuclein protein (α-syn).

Indexed as

alpha-synucleinautoantibodiesautoimmunityimmune systemmicroglia activationneurodegenerative diseaseneuroinflammationParkinson's disease

Identifiers

PMID30837941
PMCPMC6389614
OpenAlexW2916913984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.