ArticleFrontiers in physiology2019
Lifelong Football Training: Effects on Autophagy and Healthy Longevity Promotion.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Lifelong football training influences miR-1303 serum expression and human breast cancer MCF-7 cells motility: a pilot study.Frontiers in sports and active living · 2026Article
- Exercise attenuates the hallmarks of aging: Novel perspectives.Journal of sport and health science · 2025Review
- Whole-Genome Resequencing Analysis of Athletic Traits in Grassland-Thoroughbred.Animals : an open access journal from MDPI · 2025Article
- Short sleep time may be the main reason for irregular breakfast to cause overweight-a cross-sectional study.Frontiers in nutrition · 2024Article
- Bone Health, Body Composition and Physiological Demands in 70-85-Year-Old Lifelong Male Football Players.Sports (Basel, Switzerland) · 2023Article
- Article
- Football training as a non-pharmacological treatment of the global aging population-A topical review.Frontiers in aging · 2023Review
- Growing old together: What we know about the influence of diet and exercise on the aging host's gut microbiome.Frontiers in sports and active living · 2023Review
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.International journal of environmental research and public health · 2022Article
- Effects of Different Types of Chronic Training on Bioenergetic Profile and Reactive Oxygen Species Production in LHCN-M2 Human Myoblast Cells.International journal of molecular sciences · 2022Article
- RPNs Levels Are Prognostic and Diagnostic Markers for Hepatocellular Carcinoma.Journal of oncology · 2022Article
- Regular football training down-regulates miR-1303 muscle expression in veterans.European journal of applied physiology · 2021Article
- The Association Between Regular Physical Exercise, Sleep Patterns, Fasting, and Autophagy for Healthy Longevity and Well-Being: A Narrative Review.Frontiers in psychology · 2021Review
- Altered immune phenotype and DNA methylation in panic disorder.Clinical epigenetics · 2020Article
- Long-Term Recreational Football Training and Health in Aging.International journal of environmental research and public health · 2020Review
- The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage.Aging · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a physiological process characterized by a progressive decline of biological functions and an increase in destructive processes in cells and organs. Physical activity and exercise positively affects the expression of skeletal muscle markers involved in longevity pathways. Recently, a new mechanism, autophagy, was introduced to the adaptations induced by acute and chronic exercise as responsible of positive metabolic modification and health-longevity promotion. However, the molecular mechanisms regulating autophagy in response to physical activity and exercise are sparsely described. We investigated the long-term adaptations resulting from lifelong recreational football training on the expression of skeletal muscle markers involved in autophagy signaling. We demonstrated that lifelong football training increased the expression of messengers: RAD23A, HSPB6, RAB1B, TRAP1, SIRT2, and HSBPB1, involved in the auto-lysosomal and proteasome-mediated protein degradation machinery; of RPL1, RPL4, RPL36, MRLP37, involved in cellular growth and differentiation processes; of the Bcl-2, HSP70, HSP90, PSMD13, and of the ATG5-ATG12 protein complex, involved in proteasome promotion and autophagy processes in muscle samples from lifelong trained subjects compared to age-matched untrained controls. In conclusion, our results indicated that lifelong football training positively influence exercise-induced autophagy processes and protein quality control in skeletal muscle, thus promoting healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.