Evidence map›Paper›PMID 30837872›Full record

ArticleFrontiers in pharmacology2019

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation.

María Rodriguez-Serrano, Joaquín Rueda, Francisco Buendía, Fermi Monto, Jaime Aguero, Ana Osa, Oscar Cano, Luis Martínez-Dolz, Pilar D'Ocon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

María Rodriguez-SerranoServicio de Cardiología, Hospital de Manises, Valencia, Spain.
Joaquín RuedaServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Francisco BuendíaServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Fermi MontoDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Valencia, Spain.
Jaime AgueroServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Ana OsaServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Oscar CanoServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Luis Martínez-DolzServicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Pilar D'OconDepartamento de Farmacología, Facultad de Farmacia, Universitat de València, Valencia, Spain.
Hospital Universitari i Politècnic La Fe · ESUniversitat de València · ESHospital de Manises · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary regurgitation (PR) is a frequent complication after repair of congenital heart disease. Three different GRK isoforms (GRK2, GRK5, and GRK3) and two β-adrenoceptors (β1-AR and β2-AR) are present in peripheral blood mononuclear cells (PBMC) and their expression changes as a consequence of the hemodynamic and neurohumoral alterations that occur in some cardiovascular diseases. Therefore, they could be useful as biomarkers in PR. A prospective study was conducted to describe the expression (TaqMan Gene Expression Assays) of β-ARs and GRKs in PBMC isolated (Ficoll

Indexed as

congenital heart diseaseGRK2pulmonary regurgitationpulmonary valve replacementright ventricleβ2-adrenoceptor

Identifiers

PMID30837872
PMCPMC6390728
OpenAlexW2917852615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.