ArticleScientific reports2019
4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Animal origins free products in cell culture media: a new frontier.Cytotechnology · 2025Review
- Sericin/Human Placenta-Derived Extracellular Matrix Scaffolds for Cutaneous Wound Treatment-Preparation, Characterization,Pharmaceutics · 2023Article
- Multiple ways for the same destination: bone regeneration.Maxillofacial plastic and reconstructive surgery · 2022Review
- 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing.Maxillofacial plastic and reconstructive surgery · 2022Review
- The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells.Maxillofacial plastic and reconstructive surgery · 2021Article
- Immunomodulation and smart materials for maxillofacial tissue engineering.Maxillofacial plastic and reconstructive surgery · 2020Article
- Immunomodulation for maxillofacial reconstructive surgery.Maxillofacial plastic and reconstructive surgery · 2020Review
- 4-Hexylresorcinol-in duced angiogenesis potential in human endothelial cells.Maxillofacial plastic and reconstructive surgery · 2020Article
- Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.International journal of molecular sciences · 2020Article
- Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1α/VEGF signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- The Administration of 4-Hexylresorcinol Accelerates Orthodontic Tooth Movement and Increases the Expression Level of Bone Turnover Markers in Ovariectomized Rats.International journal of molecular sciences · 2020Article
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiogenesis plays an important role in active inflammation and wound healing. Our results showed that silk sericin and 4-hexylresorcinol (4HR) increased vascular endothelial growth factor (VEGF) expression in a dose-dependent manner in RAW264.7 cells. Unlike 4HR, silk sericin increased the expression of hypoxia inducible factor-1α (HIF-1α) and HIF-2α. Pretreatment with an HIF inhibitor decreased the sericin-induced increase in VEGF expression. However, the HIF inhibitor did not affect the 4HR-induced increase in VEGF expression. An inhibitor of matrix metalloproteinase (MMP) declined the 4HR-induced increase in VEGF expression. Silk sericin increased production of reactive oxygen species (ROS), whereas 4HR decreased ROS. M1 markers were increased by silk sericin treatment, and M2 markers were increased by 4HR treatment. VEGF and angiogenin expression were higher in rats treated with a 4HR-incorporated silk mat than in rats treated with a silk mat alone. In conclusion, silk sericin and 4HR increased VEGF expression in RAW264.7 cells via HIF-mediated and MMP-mediated pathways, respectively. Silk sericin exerted like pro-oxidant effects and 4HR exerted anti-oxidant effects. Rats treated with a 4HR-incorporated silk mat showed higher levels of VEGF and angiogenin than those treated with a silk mat alone.
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