Evidence map›Paper›PMID 30837600›Full record

ArticleScientific reports2019

Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals.

H V Sarin, J H Lee, M Jauhiainen, A Joensuu, K Borodulin, S Männistö, Z Jin, J D Terwilliger, V Isola, J P Ahtiainen and 4 more

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

H V SarinGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. heikki.sarin@thl.fi.
J H LeeSergievsky Center, Taub Institute and Departments of Epidemiology and Neurology, Columbia University, New York, NY, USA.ORCID 0000-0002-2000-4821
M JauhiainenGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
A JoensuuGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0002-7547-7458
K BorodulinPublic Health Evaluation and Projection Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
S MännistöPublic Health Promotion Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Z JinDepartment of Biostatistics, Columbia University, New York, NY, USA.
J D TerwilligerGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
V IsolaFaculty of Sport and Health Sciences, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.
J P AhtiainenFaculty of Sport and Health Sciences, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.
K HäkkinenFaculty of Sport and Health Sciences, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.
K KristianssonGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0003-4688-107X
J J HulmiFaculty of Sport and Health Sciences, Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.
M PerolaGenomics and Biomarkers Unit, The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.

Funding

A longitudinal study of mid-to late-life blood pressure profiles as risk factors for Alzheimer´s disease in HispanicsR03AG054186 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAESTRE, GLADYS E., TERWILLIGER, JOSEPH DOUGLAS · 2016 to 2017
$163k
NIA NIH HHS R03 AG054186
6 · The paper itself

Abstract

The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and white blood cell transcriptomic markers in healthy, normal-weight individuals. The current study examined 42 healthy, young (age: 27.5 ± 4.0 years), normal-weight (body mass index, BMI: 23.4 ± 1.7 kg/m

Indexed as

Adipose TissueBiomarkersBody CompositionBody Mass IndexBody WeightCardiovascular DiseasesDietExerciseHumansMetabolomeMetabolomicsOrgan SizePanniculitisBiomarkers

Identifiers

PMID30837600
PMCPMC6400952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.