ArticleScientific reports2019
Nucleation and Formation of a Primary Clot in Insect Blood.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Integrated respiratory metabolism and hemolymph proteome of caste specific features during honeybee (Apis mellifera L.) development.Scientific data · 2026Article
- Current insights into insect immune memory.eLife · 2025Review
- Cytoplasmic viscosity is a potential biomarker for metastatic breast cancer cells.Nanoscale advances · 2024Article
- Haemolymph viscosity in hawkmoths and its implications for hovering flight.Proceedings. Biological sciences · 2023Article
- Probing DNA-Amyloid Interaction and Gel Formation by Active Magnetic Wire Microrheology.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites.Immunology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood clotting at wound sites is critical for preventing blood loss and invasion by microorganisms in multicellular animals, especially small insects vulnerable to dehydration. The mechanistic reaction of the clot is the first step in providing scaffolding for the formation of new epithelial and cuticular tissue. The clot, therefore, requires special materials properties. We have developed and used nano-rheological magnetic rotational spectroscopy with nanorods to quantitatively study nucleation of cell aggregates that occurs within fractions of a second. Using larvae of Manduca sexta, we discovered that clot nucleation is a two-step process whereby cell aggregation is the time-limiting step followed by rigidification of the aggregate. Clot nucleation and transformation of viscous blood into a visco-elastic aggregate happens in a few minutes, which is hundreds of times faster than wound plugging and scab formation. This discovery sets a time scale for insect clotting phenomena, establishing a materials metric for the kinetics of biochemical reaction cascades. Combined with biochemical and biomolecular studies, these discoveries can help design fast-working thickeners for vertebrate blood, including human blood, based on clotting principles of insect blood.
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Registered trials
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