ArticleScientific reports2019
Early neuropathological and neurobehavioral consequences of preterm birth in a rabbit model.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pooled it
- Impact of Antenatal Corticosteroids on Respiratory and Neurodevelopmental Outcomes in the FGR Rabbit Model.Biomedicines · 2026Article
- How auditory development affects language acquisition: Influences of socioeconomic status and gestational age at birth.PloS one · 2026Article
- Dual Effect of Melatonin in Fetal Brain: Structural and Cellular Implications in a Rabbit Model of Intrauterine Growth Restriction.Molecular neurobiology · 2025Article
- Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage.Frontiers in pediatrics · 2025Article
- Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies.Pediatric research · 2024Review
- How to translate neurocognitive and behavioural outcome data in animals exposed to paracetamol to the human perinatal setting?Archives of medical science : AMS · 2024Article
- Long-term pulmonary and neurodevelopmental impairment in a fetal growth restriction rabbit model.Scientific reports · 2023Article
- The Effects of Prenatal Pravastatin Treatment in the Rabbit Fetal Growth Restriction Model.Biomedicines · 2023Article
- Fetal Growth Restriction Impairs Lung Function and Neurodevelopment in an Early Preterm Rabbit Model.Biomedicines · 2023Article
- Placental vascular alterations are associated with early neurodevelopmental and pulmonary impairment in the rabbit fetal growth restriction model.Scientific reports · 2022Article
- Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model.Pediatric research · 2022Article
- Preterm Birth Affects Early Motor Development in Pigs.Frontiers in pediatrics · 2021Article
- Effects of Maternal Abdominal Surgery on Fetal Brain Development in the Rabbit Model.Fetal diagnosis and therapy · 2021Article
- Earlier preterm birth is associated with a worse neurocognitive outcome in a rabbit model.PloS one · 2021Article
- Long-term neurological effects of neonatal caffeine treatment in a rabbit model of preterm birth.Pediatric research · 2020Article
- Article
- Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy.Journal of neurophysiology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Preterm birth is the most significant problem in contemporary obstetrics accounting for 5-18% of worldwide deliveries. Encephalopathy of prematurity encompasses the multifaceted diffuse brain injury resulting from preterm birth. Current animal models exploring the underlying pathophysiology of encephalopathy of prematurity employ significant insults to generate gross central nervous system abnormalities. To date the exclusive effect of prematurity was only studied in a non-human primate model. Therefore, we aimed to develop a representative encephalopathy of prematurity small animal model only dependent on preterm birth. Time mated New-Zealand white rabbit does were either delivered on 28 (pre-term) or 31 (term) postconceptional days by caesarean section. Neonatal rabbits underwent neurobehavioral evaluation on 32 days post conception and then were transcardially perfuse fixed. Neuropathological assessments for neuron and oligodendrocyte quantification, astrogliosis, apoptosis and cellular proliferation were performed. Lastly, ex-vivo high-resolution Magnetic Resonance Imaging was used to calculate T1 volumetric and Diffusion Tensor Imaging derived fractional anisotropy and mean diffusivity. Preterm birth was associated with a motoric (posture instability, abnormal gait and decreased locomotion) and partial sensory (less pain responsiveness and failing righting reflex) deficits that coincided with global lower neuron densities, less oligodendrocyte precursors, increased apoptosis and less proliferation. These region-specific histological changes corresponded with Magnetic Resonance Diffusion Tensor Imaging differences. The most significant differences were seen in the hippocampus, caudate nucleus and thalamus of the preterm rabbits. In conclusion this model of preterm birth, in the absence of any other contributory events, resulted in measurable neurobehavioral deficits with associated brain structural and Magnetic Resonance Diffusion Tensor Imaging findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.