Evidence map›Paper›PMID 30837573›Full record

Trial reportScientific reports2019

Hydrogen peroxide-based products alter inflammatory and tissue damage-related proteins in the gingival crevicular fluid of healthy volunteers: a randomized trial.

Valderlane L P Colares, Suellen N L Lima, Nágila C F Sousa, Mizael C Araújo, Domingos M S Pereira, Saulo J F Mendes, Simone A Teixeira, Cristina de A Monteiro, Matheus C Bandeca, Walter L Siqueira and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Evaluating the Efficiency and Tooth Sensitivity of a Novel Whitening Strip: A Randomized, Double-Blind Controlled Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Trial
  4. Efficacy and Tooth Sensitivity of Low- Versus High-Concentration Hydrogen Peroxide for In-Office Bleaching: A Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. NaNbOiScience · 2022
    Article
  11. Observational
  12. Role of Hydrogen Sulfide in Oral Disease.Oxidative medicine and cellular longevity · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Valderlane L P ColaresPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Suellen N L LimaPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Nágila C F SousaPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Mizael C AraújoPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Domingos M S PereiraPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Saulo J F MendesPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Simone A TeixeiraDepartamento de Farmacologia, Universidade de São Paulo, São Paulo, SP, Brazil.
Cristina de A MonteiroPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Matheus C BandecaPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Walter L SiqueiraSchool of Dentistry and Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada.
Eduardo B MoffaPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil.
Marcelo N MuscaráDepartamento de Farmacologia, Universidade de São Paulo, São Paulo, SP, Brazil.
Elizabeth S FernandesPrograma de Pós-graduação, Universidade Ceuma, São Luís, MA, Brazil. elizabeth.soares@ceuma.br.
Centro Universitário do Maranhão · BRUniversidade de São Paulo · BRWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen peroxide (H

Indexed as

Dose-Response Relationship, DrugFemaleGingival Crevicular FluidHealthy VolunteersHumansHydrogen PeroxideMaleNeutrophilsOxidative StressTooth BleachingTooth Bleaching AgentsHydrogen PeroxideTooth Bleaching Agents

Identifiers

PMID30837573
PMCPMC6400941
OpenAlexW2919107913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.