Evidence map›Paper›PMID 30837563›Full record

ArticleScientific reports2019

Optogenetic stimulation promotes Schwann cell proliferation, differentiation, and myelination in vitro.

Kyuhwan Jung, Ji Hye Park, Sung-Yon Kim, Noo Li Jeon, Sung-Rae Cho, Sujin Hyung

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Optogenetic and Endogenous Modulation of CaInternational journal of molecular sciences · 2025
    Review
  3. Cutting-edge technologies in neural regeneration.Cell regeneration (London, England) · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Application of Optogenetics for Muscle Cells and Stem Cells.Advances in experimental medicine and biology · 2021
    Article
  9. New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 6 countries.

Kyuhwan JungGraduate Program of Nano Science and Technology, Graduate School of Yonsei University, Seoul, Korea.
Ji Hye ParkGradaute Program of Translational Neuroscience, Institute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany.
Sung-Yon KimDepartment of Biophysics and Chemical Biology, Seoul National University, Seoul, South Korea.ORCID 0000-0003-0791-7308
Noo Li JeonMultiscale Mechanical Design School of Mechanical and Aerospace Engineering Institute of Advanced Machinery and Design, Seoul National University, Seoul, Korea. njeon@snu.ac.kr.
Sung-Rae ChoGraduate Program of Nano Science and Technology, Graduate School of Yonsei University, Seoul, Korea. SRCHO918@yuhs.ac.
Sujin HyungMultiscale Mechanical Design School of Mechanical and Aerospace Engineering Institute of Advanced Machinery and Design, Seoul National University, Seoul, Korea. smsns7230@gmail.com.
Seoul National University · KRYonsei University · KRUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schwann cells (SCs) constitute a crucial element of the peripheral nervous system, by structurally supporting the formation of myelin and conveying vital trophic factors to the nervous system. However, the functions of SCs in developmental and regenerative stages remain unclear. Here, we investigated how optogenetic stimulation (OS) of SCs regulates their development. In SC monoculture, OS substantially enhanced SC proliferation and the number of BrdU

Indexed as

Cell DifferentiationCell ProliferationLightAnimalsCalciumCalcium Channels, T-TypeCells, CulturedCoculture TechniquesCulture MediaEarly Growth Response Protein 2Inositol 1,4,5-TrisphosphateMiceMotor NeuronsMyelin Basic ProteinOptogeneticsSchwann CellsCalciumCalcium Channels, T-TypeCulture MediaEarly Growth Response Protein 2Inositol 1,4,5-TrisphosphateMyelin Basic Protein

Identifiers

PMID30837563
PMCPMC6401157
OpenAlexW2922379217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.