ArticleScientific reports2019
Inflammatory cytokines in highly myopic eyes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- The association between macronutrients intake and myopia risk: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Efficacy of Repeated Low-Level Red Light (RLRL) therapy on myopia outcomes in children: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Gonioscopy-assisted transluminal trabeculotomy with phacoemulsification in high myopia versus non-high myopia with open-angle glaucoma-A comparative study.Indian journal of ophthalmology · 2026Article
- Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression.Life science alliance · 2026Article
- Aqueous Humour Cytokines as Predictors of Axial Elongation in High Myopia: A 2-Year Longitudinal Cohort Study.Clinical & experimental ophthalmology · 2026Observational
- Article
- Atropine reinstates inflammation-induced dysregulation of dopamine and its receptors in human scleral cells: Implications for myopia therapy.Indian journal of ophthalmology · 2026Article
- Associations between blood cell profiles and low-to-medium myopia in school-aged children: a case-control study.Scientific reports · 2026Article
- Molecular and Biomechanical Changes in the Anterior Segment of High Myopic Eyes.Annals of biomedical engineering · 2026Review
- Selective retinal neuron loss and impaired neurovascular support underlie myopic retinopathy in RPE-specific Lrp2-deficient mice.Frontiers in cellular neuroscience · 2026Article
- Inflammation and Immune Pathways in Myopia: An Overview on Pathomechanisms and Treatment Prospects.Clinical reviews in allergy & immunology · 2025Review
- Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia Development.Investigative ophthalmology & visual science · 2025Article
- Exploration of correlated factors of axial length changes after repeated low-level red-light irradiation in the real world.BMC ophthalmology · 2025Article
- Integrated genomics reveals cellular senescence-driven molecular networks and immune crosstalk in myopia pathogenesis.Journal of cell communication and signaling · 2025Article
- Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study.Translational vision science & technology · 2025Article
- The role of NF-κB pathway and its regulation of inflammatory cytokines in scleral remodeling of form-deprivation mice model.Immunologic research · 2025Article
- The role of inflammation in myopic retinopathy.Frontiers in ophthalmology · 2025Review
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Expression of LncRNAs in anterior capsule of lens in patients with pathologic myopia complicated with cataract.International ophthalmology · 2024Article
- Reduced retinol (vitamin A) and α-tocopherol (vitamin E) blood levels and increased myeloperoxidase (MPO) activity in children with high myopia.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, myopic retinopathy is the most common irreversible blinding disease but its pathophysiology is not completely clear. A cross-sectional, observational study was conducted in a single center to analyze aqueous samples from highly myopic eyes (axial length >25 mm, n = 92) and ametropic or mild myopic eyes (n = 88) for inflammatory cytokines. Vascular endothelial growth factor (VEGF), Interleukin 6 (IL-6), and matrix metalloproteinase-2 (MMP-2) were measured using an enzyme-linked immunosorbent assay. IL-6 and MMP-2 were significantly higher in the highly myopic eyes than in the non-high myopic eyes (IL-6: 11.90 vs. 4.38 pg/mL, p < 0.0001; MMP-2: 13.10 vs. 8.82 ng/mL, p = 0.0003) while adjusting for age, gender, and intraocular pressure. There was a significant positive association between levels of IL-6 and MMP-2 in aqueous humor and the axial lengths of the eye globes (IL-6, β = 0.065, p < 0.0001, n = 134; MMP-2, β = 0.097, p < 0.0001, n = 131). Conversely, VEGF in aqueous humor was significantly lower in the highly myopic eyes than in the non-high myopic eyes (45.56 vs. 96.90 pg/mL, p < 0.0001, n = 153) while age, gender, and intraocular pressure were adjusted. The results suggest that low-grade intraocular inflammation may play an important role in the development and progression of high myopia and myopic retinopathy.
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Registered trials
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