ArticleScientific reports2019
Pyroglutamic acidosis as a cause for high anion gap metabolic acidosis: a prospective study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- A new wide-scope, multi-biomarker wastewater-based epidemiology analytical method to monitor the health and well-being of inhabitants at a metropolitan scale.Analytical and bioanalytical chemistry · 2025Article
- Article
- Drug-Related Pyroglutamic Acidosis: Systematic Literature Review.Journal of clinical medicine · 2024Article
- Pyroglutamic acidosis in the setting ofClinical case reports · 2024Article
- Pyroglutamate acidosis 2023. A review of 100 cases.Clinical medicine (London, England) · 2024Review
- Severe Anion Gap Metabolic Acidosis Resulting from Combined Chronic Acetaminophen Toxicity and Starvation Ketosis: A Case Report and Literature Review.The American journal of case reports · 2022Review
- Acquired pyroglutamic acidaemia in a critically ill patient with chronic paracetamol use: A case report.SAGE open medical case reports · 2022Article
- Flucloxacillin and paracetamol induced pyroglutamic acidosis.BMJ case reports · 2021Article
- Metabolomics Study of Serum from a Chronic Alcohol-Fed Rat Model Following Administration of DefattedMetabolites · 2020Article
- Acquired pyroglutamic acidosis due to long-term dicloxacillin and paracetamol use.BMJ case reports · 2020Article
- Recurrent Pyroglutamic Acidosis in the Context of Undiagnosed Liver Cirrhosis-A Case Report.Journal of clinical and experimental hepatologyArticle
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-oxoprolinemia (pyroglutamic acid, PGA) in the absence of acetaminophen use has been rarely reported as a cause for high anion gap metabolic acidosis. We investigated the prevalence and risk factors for elevated PGA concentrations among hospitalized patients with high anion gap metabolic acidosis: We prospectively enrolled patients with high anion gap metabolic acidosis hospitalized in the department of medicine. For each patient we collected the main diagnosis, concurrent medications and laboratory parameters. Spot urine samples were tested for PGA concentration. Levels ≥63 µmol/mmol creatinine were considered elevated. Overall, forty patients were prospectively followed. Mean age was 66.9 (17.9) years. Four (6.3%) patients had a high urine PGA level and demonstrated also lower blood pH (7.2 vs 7.3, p = 0.05) and lower serum lactate concentration (17.5 mg/dl vs 23.0 mg/dl, p = 0.04). Additionally, the high PGA level group consisted of more patients with septic shock [2/4 (50%) vs 3/36 (8.3%)] with a trend towards significance (p = 0.07). In conclusion, PGA might have a role in patients with septic shock and acidosis. Being a treatable condition, PGA should be taken into consideration particularly when no other cause for high anion gap is identified.
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